119-48-2

• 常用中文名：双吗啉胺
• 常用英文名：N,N'-ethylenebis(N-butylmorpholine-4-carboxamide)
• CAS号：119-48-2
• 分子式：C₂₀H₃₈N₄O₄
• 分子量：398.54000
• 相关类别： 分析化学 分析试剂 离子色谱试剂
• 发布时间：2018-08-02 16:45:01
• 更新时间：2024-01-03 19:01:28

名称

• 中文名: 双吗啉胺
• 英文名: N-butyl-N-[2-[butyl(morpholine-4-carbonyl)amino]ethyl]morpholine-4-carboxamide
• 英文别名: dimorpholamine; Atmurin; EINECS 204-328-7; Prontodin; N,N'-dibutyl-N,N'-ethanediyl-bis-morpholine-4-carboxamide; N,N'-Dibutyl-N,N'-aethandiyl-bis-morpholin-4-carbamid; Theraleptique; Theraptique; 1064 TH; Amipan T

物化性质

• 密度: 1.114g/cm3
• 沸点: 571.3ºC at 760mmHg
• 分子式: C₂₀H₃₈N₄O₄
• 分子量: 398.54000
• 闪点: 299.3ºC
• 精确质量: 398.28900
• PSA: 65.56000
• LogP: 1.97080
• 蒸汽压: 4.63E-13mmHg at 25°C
• 折射率: 1.516
• 分子结构:

  1、 摩尔折射率：108.10

  2、 摩尔体积（cm³/mol）：357.6

  3、 等张比容（90.2K）：928.5

  4、 表面张力（dyne/cm）：45.4

  5、 极化率（10-24cm3）：42.85

• 计算化学:

  1.疏水参数计算参考值（XlogP）:1

  2.氢键供体数量:0

  3.氢键受体数量:4

  4.可旋转化学键数量:9

  5.互变异构体数量:无

  6.拓扑分子极性表面积65.6

  7.重原子数量:28

  8.表面电荷:0

  9.复杂度:423

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QD9800000 CHEMICAL NAME : 4-Morpholinecarboxamide, N,N'-ethylenebis(N-butyl- CAS REGISTRY NUMBER : 119-48-2 BEILSTEIN REFERENCE NO. : 0052277 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C20-H38-N4-O4 MOLECULAR WEIGHT : 398.62 WISWESSER LINE NOTATION : T6N DOTJ AVN4&2N4&V- AT6N DOTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 270 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,347,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 190 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,347,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 24 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,347,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 122 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,347,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 380 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 163,133,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 163,133,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 104 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 163,133,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 42200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,347,1982

安全

• 海关编码: 2934999090

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%