305-53-3

• 常用中文名：碘代乙酸钠盐
• 常用英文名：sodiumiodoacetate
• CAS号：305-53-3
• 分子式：C₂H₂INaO₂
• 分子量：207.930
• 相关类别： 有机原料 有机金属类化合物 有机钠
• 发布时间：2018-03-29 08:00:00
• 更新时间：2024-01-04 18:54:22
• 【用途一】
  用于制药工业
  【用途二】
  用于蛋白质中修饰胱氨酸残基的试剂

名称

• 中文名: 碘代乙酸钠盐
• 英文名: sodium,2-iodoacetate
• 中文别名: 碘乙酸钠盐; 碘乙酸钠
• 英文别名: lithium iodoacetate; sodiumiodoacetate; Sodium monoiodoacetate; EINECS 206-165-7; Sodium iodacetate; USAF EK-6279; 2-iodoacetic acid sodium salt; Iodoacetic acid sodium salt; Sodium iodoacetate; Iodoacetic acid,sodium salt; Acetic acid, 2-iodo-, sodium salt (1:1); MFCD00002686; Iodoacetate,sodium salt

物化性质

• 沸点: 262.1ºC at 760mmHg
• 熔点: 208 °C (dec.)(lit.)
• 分子式: C₂H₂INaO₂
• 分子量: 207.930
• 闪点: 112.3ºC
• 精确质量: 207.899704
• PSA: 40.13000
• 外观性状: 淡黄色至黄色-棕色粉末
• 储存条件: 密封干燥避光保存
• 水溶解性: methanol: 0.1 M at 20 °C, clear, colorless
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:2

  4.可旋转化学键数量:1

  5.互变异构体数量:无

  6.拓扑分子极性表面积40.1

  7.重原子数量:6

  8.表面电荷:0

  9.复杂度:46.8

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

• 更多:

  一、物性数据

  性状：白色结晶粉末。在空气中吸湿

  密度（g/mL,25/4℃）：不可用

  相对蒸汽密度（g/mL,空气=1）：不可用

  熔点（ºC）：208-210

  沸点（ºC,常压）：不可用

  沸点（ºC,5.2kPa）：不可用

  折射率：不可用

  闪点（ºC）：不可用

  比旋光度（º）：不可用

  自燃点或引燃温度（ºC）：不可用

  蒸气压（kPa,25ºC）：不可用

  饱和蒸气压（kPa,60ºC）：不可用

  燃烧热（KJ/mol）：不可用

  临界温度（ºC）：不可用

  临界压力（KPa）：不可用

  油水（辛醇/水）分配系数的对数值：不可用

  爆炸上限（%,V/V）：不可用

  爆炸下限（%,V/V）：不可用

  溶解性：溶于水，不溶于醇、醚和丙酮。

MSDS

Name: Iodoacetic acid sodium salt 99% Material Safety Data Sheet Synonym: Sodium iodoacetate; sodium monoiodoacetat CAS: 305-53-3 Section 1 - Chemical Product MSDS Name:Iodoacetic acid sodium salt 99% Material Safety Data Sheet Synonym:Sodium iodoacetate; sodium monoiodoacetat Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 305-53-3 Iodoacetic acid, sodium salt 99.0 206-165-7 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Hygroscopic (absorbs moisture from the air).The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: No information regarding eye irritation and other potential effects was found. Skin: No information regarding skin irritation and other potential effects was found. Ingestion: The toxicological properties of this substance have not been fully investigated. Inhalation: The toxicological properties of this substance have not been fully investigated. Inhalation of dust may cause respiratory tract irritation. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 305-53-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: yellow Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 208.00 - 210.00 deg C Autoignition Temperature: Not available. Flash Point: 208 deg C ( 406.40 deg F) Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: 208 deg C Solubility in water: soluble Specific Gravity/Density: Molecular Formula: C2H2IO2Na Molecular Weight: 207.93 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, moisture. Incompatibilities with Other Materials: Oxidizing agents Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, toxic fumes of sodium oxide, hydrogen iodide, iodine. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 305-53-3: AI3675000 LD50/LC50: CAS# 305-53-3: Oral, mouse: LD50 = 83 mg/kg. Carcinogenicity: Iodoacetic acid, sodium salt - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.* Hazard Class: 6.1 UN Number: 2811 Packing Group: III IMO Shipping Name: TOXIC SOLID, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: 2811 Packing Group: III RID/ADR Shipping Name: TOXIC SOLID, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: 2811 Packing group: III Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 22 Do not breathe dust. S 24/25 Avoid contact with skin and eyes. S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 305-53-3: No information available. Canada CAS# 305-53-3 is listed on Canada's DSL List. CAS# 305-53-3 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 305-53-3 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 二、毒理学数据： 有毒，半数致死量（小鼠，经口）63mg/kg。有腐蚀性 生态学数据: 三、生态学数据： 1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。 CHEMICAL IDENTIFICATION RTECS NUMBER : AI3675000 CHEMICAL NAME : Acetic acid, iodo-, sodium salt CAS REGISTRY NUMBER : 305-53-3 LAST UPDATED : 199710 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C2-H2-I-O2.Na MOLECULAR WEIGHT : 207.93 WISWESSER LINE NOTATION : OV1I &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 83 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 500 mg/kg SEX/DURATION : female 8-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 10 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,59,1996

安全

• 符号: GHS05, GHS06
• 信号词: Danger
• 危害声明: H301-H315-H318-H335
• 警示性声明: P261-P280-P301 + P310-P305 + P351 + P338
• 个人防护装备: Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
• 危害码 (欧洲): T:Toxic;
• 风险声明 (欧洲): R25;R36/37/38
• 安全声明 (欧洲): S26-S39-S45
• 危险品运输编码: UN 2811 6.1/PG 1
• WGK德国: 3
• RTECS号: AI3675000
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2915900090

上下游产品

上游产品  0
下游产品  10
191542-37-7 613-31-0 23825-24-3 131581-34-5
889952-83-4 172531-37-2 113815-00-2 20057-39-0
22245-55-2 82243-05-8

海关

海关编码	2915900090
中文概述	2915900090. 其他饱和无环一元羧酸及其酸酐（酰卤、过氧）化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%