104366-23-6

• 常用中文名：2-氨基-4-氯-3-氰基-5-甲酰基噻吩
• 常用英文名：2-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile
• CAS号：104366-23-6
• 分子式：C₆H₃ClN₂OS
• 分子量：186.619
• 相关类别： 医药中间体 杂环化合物 噻吩类化合物
• 发布时间：2018-12-28 15:14:49
• 更新时间：2024-01-08 19:31:52
• 下载msds

名称

• 中文名: 2-氨基-4-氯-3-氰基-5-甲酰基噻吩
• 英文名: 2-Amino-3-Cyano-4-Chloro-5-Formylthiophene
• 中文别名: 2-氨基-4-氯-5-甲酰基噻吩-3-甲腈; 2-氨基-3-氰基-4-氯-5-甲醛基噻吩
• 英文别名: 2-Amino-4-chloro-3-cyano-5-formylthiophene; 3-Thiophenecarbonitrile, 2-amino-4-chloro-5-formyl-; MFCD03788265; 2-amino-4-chloro-5-formylthiophene-3-carbonitrile; T5SJ BZ CCN DG EVH; 2-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 366.3±42.0 °C at 760 mmHg
• 熔点: 269 °C(dec.)
• 分子式: C₆H₃ClN₂OS
• 分子量: 186.619
• 闪点: 175.3±27.9 °C
• 精确质量: 185.965454
• PSA: 95.12000
• LogP: 2.08
• 外观性状: 固体;Light yellow to Brown powder to crystal
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.646
• 储存条件: 2-8°C
• 分子结构:

  1、 摩尔折射率：42.87

  2、 摩尔体积（cm³/mol）：118.0

  3、 等张比容（90.2K）：350.1

  4、 表面张力（dyne/cm）：77.3

  5、 极化率（10-24cm3）：16.99

• 计算化学:

  1.疏水参数计算参考值（XlogP）:1.9

  2.氢键供体数量:1

  3.氢键受体数量:4

  4.可旋转化学键数量:1

  5.互变异构体数量:4

  6.拓扑分子极性表面积95.1

  7.重原子数量:11

  8.表面电荷:0

  9.复杂度:214

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

MSDS

Section1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE Product identifiers Product name: 2-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile CAS-No.: 104366-23-6 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances Section2. HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Acute toxicity, Oral (Category 3) Skin corrosion (Category 1B) Skin sensitization (Category 1) Classification according to EU Directives 67/548/EEC or 1999/45/EC Harmful if swallowed. May cause sensitization by skin contact. Causes burns. Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal wordDanger Hazard statement(s) H301Toxic if swallowed. H314Causes severe skin burns and eye damage. H317May cause an allergic skin reaction. Precautionary statement(s) P280Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P305 + P351 + P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310Immediately call a POISON CENTER or doctor/ physician. Supplemental Hazardnone Statements According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R22Harmful if swallowed. R43May cause sensitization by skin contact. R34Causes burns. S-phrase(s) S26In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39Wear suitable protective clothing, gloves and eye/face protection. S45In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Other hazards Lachrymator. Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substances Synonyms: 2-Amino-3-cyano-4-chlorothiophene-5-carboxaldehyde Formula: C6H3ClN2OS Molecular Weight: 186,62 g/mol ComponentConcentration 2-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile CAS-No.104366-23-6- Section4. FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed Cough, Shortness of breath, Headache, Nausea, Vomiting Indication of any immediate medical attention and special treatment needed no data available Section5. FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Sulphur oxides, Hydrogen chloride gas Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available Section6. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. Section7. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 °C Light sensitive. Heat sensitive. Stench. Specific end uses no data available Section8. EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Section9. PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) AppearanceForm: solid b) OdourStench. c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingMelting point/range: 270 - 271 °C point f) Initial boiling point and no data available boiling range g) Flash pointno data available h) Evaporation rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative densityno data available n) Water solubilityno data available o) Partition coefficient: n- no data available octanol/water p) Autoignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available Section10. STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Oxidizing agents, acids Hazardous decomposition products Other decomposition products - no data available Section11. TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity no data available Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization May cause allergic skin reaction. Germ cell mutagenicity no data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity no data available Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects Inhalation May be harmful if inhaled. Material is extremely destructive to the tissue of the mucous membranes and upper respiratory tract. IngestionToxic if swallowed. Causes burns. SkinMay be harmful if absorbed through skin. Causes skin burns. Eyes Causes eye burns. Signs and Symptoms of Exposure Cough, Shortness of breath, Headache, Nausea, Vomiting Additional Information RTECS: Not available Section12. ECOLOGICAL INFORMATION Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects no data available Section13. DISPOSAL CONSIDERATIONS Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. Section14. TRANSPORT INFORMATION UN number ADR/RID: 2923IMDG: 2923IATA: 2923 UN proper shipping name ADR/RID: CORROSIVE SOLID, TOXIC, N.O.S. (2-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile) IMDG: CORROSIVE SOLID, TOXIC, N.O.S. (2-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile) IATA:Corrosive solid, toxic, n.o.s. (2-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile) Transport hazard class(es) ADR/RID: 8 (6.1)IMDG: 8 (6.1)IATA: 8 (6.1) Packaging group ADR/RID: IIIIMDG: IIIIATA: III Environmental hazards ADR/RID: noIMDG Marine pollutant: noIATA: no Special precautions for user no data available Section15. REGULATORY INFORMATION This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment no data available Section16. OTHER INFORMATION Further information Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

安全

• 符号: GHS05, GHS06
• 信号词: Danger
• 危害声明: H301-H314-H317
• 警示性声明: P280-P301 + P310-P305 + P351 + P338-P310
• 个人防护装备: Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): Xi:Irritant;
• 风险声明 (欧洲): 22-34-43
• 安全声明 (欧洲): 26-36/37/39-45
• 危险品运输编码: UN 2923 6.1(8) / PGIII
• 包装等级: III
• 海关编码: 2934999090

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%