19431-84-6

• 常用中文名：莪术烯醇
• 常用英文名：Curcumenol
• CAS号：19431-84-6
• 分子式：C₁₅H₂₂O₂
• 分子量：234.33
• 相关类别： 信号通路 代谢酶/蛋白酶 细胞色素P450
• 发布时间：2018-09-13 10:56:24
• 更新时间：2024-01-02 09:43:08
• Curcumenol 是一种具有药用价值的姜黄属植物的重要提取物。

名称

• 中文名: 莪术醇
• 英文名: curcumenol
• 英文别名: (1S,2S,5S,8R)-9-Isopropylidene-2,6-dimethyl-11-oxatricyclo[6.2.1.0]undec-6-en-8-ol; (3S,3aS,6R,8aS)-1,2,3,4,5,8a-hexahydro-3,8-dimethyl-5-(1-methylethylidene)-6H-3a,6-epoxyazulen-6-ol; (3S,3aS,8aS)-3,8-dimethyl-5-(propan-2-ylidene)-1,2,3,4,5,8a-hexahydro-6H-3a,6-epoxyazulen-6-ol; (3S,3aS,6R,8aS)-3,8-dimethyl-5-(propan-2-ylidene)-1,2,3,4,5,8a-hexahydro-6H-3a,6-epoxyazulen-6-ol; Curcumenol; (1S,2S,5S,8R)-9-isopropylidene-2,6-dimethyl-11-oxatricyclo[6.2.1.01,5]undec-6-en-8-ol; 3,8-dimethyl-5-(1-methylethylidene)-,(3S,3aS,6R,8aS); 6H-3a,6-Epoxyazulen-6-ol, 1,2,3,4,5,8a-hexahydro-3,8-dimethyl-5-(1-methylethylidene)-, (3S,3aS,6R,8aS)-; (3S,3alphaS,6R,8alphaS)-1,2,3,4,5,8alpha-Hexahydro-3,8-dimethyl-5-(1-methylethylidene)-6H-3alpha,6-epoxyazulen-6-ol; 6H-3a,6-Epoxyazulen-6-ol,1,2,3,4,5,8a-hexahydro

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 349.3±42.0 °C at 760 mmHg
• 分子式: C₁₅H₂₂O₂
• 分子量: 234.33
• 闪点: 146.7±22.1 °C
• 精确质量: 234.161987
• PSA: 29.46000
• LogP: 3.40
• 外观性状: 白色针状结晶
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.553
• 储存条件: 2-8°C

生物活性

• 描述: Curcumenol 是一种具有药用价值的姜黄属植物的重要提取物。
• 相关类别:
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Hamdi OA, et al. Spectrofluorometric and Molecular Docking Studies on the Binding of Curcumenol and Curcumenone to Human Serum Albumin. Int J Mol Sci. 2015 Mar 6;16(3):5180-93.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KC5020000 CHEMICAL NAME : 6H-3a,6-Epoxyazulen-6-ol, 1,2,3,4,5,8a-hexahydro-3,8-dimethyl-5-(1-methylethyli dene)-, (3S-(3-alpha,3a-alpha,6-alpha,8a-beta))- CAS REGISTRY NUMBER : 19431-84-6 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C15-H22-O2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85PEAG "Zhongliu Yanjiu" Cancer Review, Yu, R., et al., eds., Shanghai Science/Technology Publisher, Peop. Rep. China, 1994 Volume(issue)/page/year: -,178,1994

合成路线

38230-32-9 ~88% 19431-84-6

文献：Shiobara, Yoshinori; Iwata, Tomoko; Kodama, Mitsuaki; Asakawa, Yoshinori; Takemoto, Tsunematsu; Fukazawa, Yoshimasa Tetrahedron Letters, 1985 , vol. 26, # 7 p. 913 - 916

38230-32-9 ~0% 19431-84-6 24063-71-6

文献：Shiobara, Yoshinori; Iwata, Tomoko; Kodama, Mitsuaki; Asakawa, Yoshinori; Takemoto, Tsunematsu; Fukazawa, Yoshimasa Tetrahedron Letters, 1985 , vol. 26, # 7 p. 913 - 916

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