毒理学数据:
二、毒理学数据：
急性毒性：不可用。
生态学数据:
三、生态学数据：
1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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SH6825000
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CHEMICAL NAME :
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Phenethylamine, N-ethyl-alpha-methyl-m-(trifluoromethyl)-, hydrochloride
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CAS REGISTRY NUMBER :
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404-82-0
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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16
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MOLECULAR FORMULA :
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C12-H16-F3-N.Cl-H
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MOLECULAR WEIGHT :
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267.75
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WISWESSER LINE NOTATION :
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FXFFR C1Y1&M2 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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36 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - sleep Behavioral - tremor
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human
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DOSE/DURATION :
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7 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - changes in motor activity (specific assay) Gastrointestinal - nausea or vomiting
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - child
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DOSE/DURATION :
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70 mg/kg
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TOXIC EFFECTS :
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Cardiac - other changes
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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69 mg/kg
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TOXIC EFFECTS :
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Behavioral - fluid intake
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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90 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
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170 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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92 mg/kg
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TOXIC EFFECTS :
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Behavioral - food intake (animal) Behavioral - changes in motor activity (specific assay)
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
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90 mg/kg
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TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Mammal - dog
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DOSE/DURATION :
-
100 mg/kg
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TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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23 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - alteration of classical conditioning
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
-
Mammal - cat
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DOSE/DURATION :
-
60 mg/kg
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TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
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TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
50 mg/kg
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TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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100 mg/kg
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TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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280 mg/kg
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SEX/DURATION :
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female 7-20 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - behavioral
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TYPE OF TEST :
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Cytogenetic analysis
MUTATION DATA
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TEST SYSTEM :
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Rodent - mouse
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DOSE/DURATION :
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1500 ug/kg
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REFERENCE :
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EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 19,323,1992
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