7150-23-4

• 常用中文名：6-甲氧基-3-吡啶羧胺
• 常用英文名：JBSNF-000088
• CAS号：7150-23-4
• 分子式：C₇H₈N₂O₂
• 分子量：152.15100
• 发布时间：2018-02-14 08:00:00
• 更新时间：2024-01-13 05:37:12
• JBSNF-000088 (6-Methoxynicotinamide) 是烟酰胺 (NA) 的类似物,是一种有效的 NNMT (烟酰胺 N-甲基转移酶) 抑制剂,对人 NNMT,猴 NNMT 和小鼠 NNMT 的 IC50 分别为 1.8 µM,2.8 µM 和 5.0 µM。在代谢性疾病的动物模型中,JBSNF-000088 抑制 NNMT 活性,降低 MNA 水平并驱动胰岛素增敏,调节葡萄糖和减轻体重。

名称

• 中文名: 6-甲氧基-3-吡啶羧胺
• 英文名: 6-Methoxynicotinamide
• 英文别名: 6-methoxypyridine-3-carboxamide

物化性质

• 密度: 1.213g/cm3
• 沸点: 301.6ºC at 760mmHg
• 分子式: C₇H₈N₂O₂
• 分子量: 152.15100
• 闪点: 136.2ºC
• 精确质量: 152.05900
• PSA: 65.21000
• LogP: 0.88940
• 折射率: 1.55
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: JBSNF-000088 (6-Methoxynicotinamide) 是烟酰胺 (NA) 的类似物,是一种有效的 NNMT (烟酰胺 N-甲基转移酶) 抑制剂,对人 NNMT,猴 NNMT 和小鼠 NNMT 的 IC50 分别为 1.8 µM,2.8 µM 和 5.0 µM。在代谢性疾病的动物模型中,JBSNF-000088 抑制 NNMT 活性,降低 MNA 水平并驱动胰岛素增敏,调节葡萄糖和减轻体重。
• 靶点:

  IC50: 1.8 µM (human NNMT), 2.8 µM (monkey NNMT) and 5.0 µM (mouse NNMT)[1]

• 体外研究: JBSNF-000088(6-甲氧基烟酰胺)对U2OS或分化的3T3L1细胞的IC50值分别为1.6和6.3μM[1]。
• 体内研究: JBSNF-000088(6-甲氧基烟酰胺)(50 mg/kg；口服给药途径4周)显示体重(%)有统计学意义上的显着降低,并导致第21天进食血糖的统计学显着降低[1]。。JBSNF-000088(50 mg/kg；口服强饲法给药；每日两次,持续四周)导致第28天口服葡萄糖耐量的统计学显着改善,葡萄糖耐量正常化[1]。JBSNF-000088(1 mg/kg；静脉注射；4小时)导致血浆清除率低至21 mL/min▪kg,稳态分布容积为0.7 L/kg,血浆半衰期非常短静脉注射0.5小时[1]。JBSNF-000088(10 mg/kg；口服强饲；4小时)导致Cmax为3568 ng/mL,Tmax值为0.5小时,表明肠道快速吸收,口服半衰期为0.4小时管饲法。发现口服生物利用度约为40%[1]。动物模型：高脂饮食(HFD)诱导的肥胖小鼠[1]剂量：50 mg/kg给药：口服给药途径,持续4周；口服强饲法给药和每天两次,持续四周结果：显示体重(%)的统计学显着降低,并且通过口服给药途径在第21天导致进食血糖的统计学显着降低。导致第28天口服葡萄糖耐量的统计学显着改善,通过口服强饲法给药使葡萄糖耐量正常化。动物模型：C57BL/6小鼠[1]剂量：1 mg/kg(静脉注射给药)；10 mg/kg(口服强饲法)(药代动力学研究)给药：静脉注射和口服强饲法；4小时结果：导致低血浆清除率为21 mL/min▪kg,稳态分布容积为0.7 L/kg,血浆半衰期非常短静脉内给药0.5小时。导致Cmax为3568ng/mL,Tmax值为0.5小时,表明肠道快速吸收,口服强饲法半衰期为0.4小时。
• 参考文献:

  [1]. Kannt A, et al. A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep. 2018 Feb 26;8(1):3660.

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: 6-Methoxynicotinamide Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:6-Methoxynicotinamide CAS number:7150-23-4 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C7H8N2O2 Molecular weight:152.2 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 海关编码: 2933399090

合成路线

67-56-1 98-92-0 ~2% 6960-22-1 7250-52-4 详细

文献：Sugimori, Akira; Itoh, Hiroshi; Kanai, Mitsuharu; Itoh, Nobuko; Sugiyama, Toru Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 8 p. 2837 - 2846

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海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%