890005-22-8

• 常用中文名：4,5,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)-1H-INDAZOLE
• 常用英文名：4,5,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)-1H-INDAZOLE
• CAS号：890005-22-8
• 分子式：C₈H₉F₃N₂
• 分子量：190.16600
• 发布时间：2016-01-12 10:05:04
• 更新时间：2024-01-09 13:44:11

名称

• 英文名: 3-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole
• 英文别名: 4,5,6,7-tetrahydro-3-trifluoromethyl-1H-indazole; 4,5,6,7-tetrahydro-3-(trifluoromethyl)-indazole; Flumatinib mesylate; 4-[(4-methylpiperazin-1-yl)methyl]-N-{6-methyl-5-[(4-(pyrid-3-yl)pyrimid-2-yl)amino]pyrid-3-yl}-3-(trifluoromethyl)benzamide methanesulfonate; 3-trifluoromethyl-4-(4-methylpiperazin-1-ylmethyl)-N-[2-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino-pyridin-5-yl]benzamide mesylate; 3-trifluoromethyl-4,5,6,7-tetrahydro-1H-indazole; 3-(trifluoromethyl)-4,5,6,7-tetrahydroindazole

物化性质

• 分子式: C₈H₉F₃N₂
• 分子量: 190.16600
• 精确质量: 190.07200
• PSA: 28.68000
• LogP: 2.30730

合成路线

387-89-3 ~66% 890005-22-8

文献：Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L. Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263

6425-41-8 407-25-0 ~67% 890005-22-8

文献：Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L. Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263

658-78-6 ~20% 890005-22-8

文献：PFIZER PRODUCTS INC. Patent: WO2008/17932 A2, 2008 ; Location in patent: Page/Page column 82-83 ;

56734-75-9 ~95% 890005-22-8

文献：Tang, Xiao-Qing; Hu, Chang-Ming Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 8 p. 1039 - 1044

108-94-1 ~% 890005-22-8

文献：Teichert, Johannes; Oulie, Pascal; Jacob, Kane; Vendier, Laure; Etienne, Michel; Claramunt, Rosa M.; Lopez, Concepcion; Perez Medina, Carlos; Alkorta, Ibon; Elguero, Jose New Journal of Chemistry, 2007 , vol. 31, # 6 p. 936 - 946

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