109882-25-9

• 常用中文名：5-[双(2-氯乙基)氨基]-1-甲基-1H-苯并咪唑-2-丁酸甲基酯
• 常用英文名：Methyl 4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2- yl}butanoate
• CAS号：109882-25-9
• 分子式：C₁₇H₂₃Cl₂N₃O₂
• 分子量：372.28900
• 发布时间：2018-12-27 14:19:25
• 更新时间：2024-01-03 10:57:12

名称

• 中文名: 5-[双(2-氯乙基)氨基]-1-甲基-1H-苯并咪唑-2-丁酸甲酯
• 英文名: Methyl 4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2- yl}butanoate
• 英文别名: Methylhydroxy-Celecoxib; PRIMARY ALCOHOL METABOLITE OF CELECOXIB; bendamustine methyl ester; 4'-Hydroxycelecoxib; Hydroxy Celecoxib; Celecoxib metabolite M3

物化性质

• 分子式: C₁₇H₂₃Cl₂N₃O₂
• 分子量: 372.28900
• 精确质量: 371.11700
• PSA: 47.36000
• LogP: 3.35300

合成路线

1221157-11-4 79-11-8 ~99% 109882-25-9

文献：CEPHALON, INC.; CHEN, Jian; PRZYUSKI, Katrin; ROEMMELE, Renee, Caroline Patent: WO2010/42568 A1, 2010 ; Location in patent: Page/Page column 19-20 ;

67-56-1 3543-75-7 ~91% 109882-25-9

文献：CEPHALON, INC.; BAKALE, Roger, P.; BROWN, Peter, D.; CHEN, Jian; DRAGER, Anthony, S.; LABELL, Rachel, Y.; MCKEAN, Robert, E.; PATEL, Piyush, R.; ROEMMELE, Renee, C. Patent: WO2014/75035 A1, 2014 ; Location in patent: Page/Page column 15 ;

109882-31-7 ~% 109882-25-9

文献：Arevipharma GmbH; Schickaneder, Helmut; Schickaneder, Christian; Limmert, Michael Patent: US2013/184471 A1, 2013 ; Location in patent: Paragraph 0146; 0147; 0148; 0149; 0150 ;

1221157-09-0 ~% 109882-25-9

文献：Chen, Jian; Przyuski, Katrin; Roemmele, Renee; Bakale, Roger P. Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1063 - 1072

1221157-10-3 ~% 109882-25-9

文献：Chen, Jian; Przyuski, Katrin; Roemmele, Renee; Bakale, Roger P. Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1063 - 1072

1501-26-4 ~% 109882-25-9

文献：Chen, Jian; Przyuski, Katrin; Roemmele, Renee; Bakale, Roger P. Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1063 - 1072

97-02-9 ~% 109882-25-9

文献：Chen, Jian; Przyuski, Katrin; Roemmele, Renee; Bakale, Roger P. Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1063 - 1072

3543-75-7 ~% 109882-25-9

文献：Werner; Letsch; Ihn Pharmazie, 1987 , vol. 42, # 4 p. 272 - 273

186581-53-3 16506-27-7 ~% 109882-25-9

文献：Werner; Letsch; Ihn Pharmazie, 1987 , vol. 42, # 4 p. 272 - 273

上下游产品

上游产品  10
1221157-11-4 79-11-8 67-56-1 3543-75-7
109882-31-7 1221157-09-0 1221157-10-3 1501-26-4
97-02-9 186581-53-3
下游产品  1
3543-75-7