154026-95-6

• 常用中文名：瑞舒伐他汀中间体C-4
• 常用英文名：(4R-Cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-aceticacid,1,1-dimethylethylester
• CAS号：154026-95-6
• 分子式：C₁₅H₂₆O₆
• 分子量：302.363
• 发布时间：2018-06-12 00:01:15
• 更新时间：2024-01-05 20:56:07

名称

• 中文名: (4R-cis)-6-[(乙酰氧基)甲基]-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯
• 英文名: tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate
• 中文别名: 罗素伐他汀钙中间体 C-1; 1 D-5(4R-CIS)-6-[(乙酰氧基)甲基]-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯; 2-[(4R,6S)-2,2-二甲基-6-(乙酰氧甲基)-1,3-二噁烷-4-基]乙酸叔丁酯; 6-乙酰氧甲基-2,2-二甲基-1,3-二氧戊环-乙酸叔丁酯 (瑞舒伐他汀中间体); 4R-顺-6-乙酰氧基甲基-2,2-二甲基-1,3-二氧杂-4-乙酸异丙酯(D5); 瑞舒伐他汀钙杂质 01
• 英文别名: (4R,6S)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid; tert-butyl 6-O-acetyl-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonate; tert-Butyl (4R-cis); 6S)-6-(acetoxyMethyl)-2; (4R-CIS)-6-[ (ACETYLOXY)METHYL ]-2,2-DIMETHYL-1; 1,1-dimethylethylester; D-erythro-Hexonic acid, 2,4-dideoxy-3,5-O-(1-methylethylidene)-, 1,1-dimethylethyl ester, acetate; MFCD08458213; tert-butyl 2-[(4R,6S)-6-(acetoxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate; tert-Butyl(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate; tert-Butyl 6-O-acetyl-2,4-dideoxy-3,5-O-isopropylidene-D-erythro-hexonate; tert-butyl 2-((4R; 3-dioxan-4-yl)acetate; (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester; 2-Methyl-2-propanyl 6-O-acetyl-2,4-dideoxy-3,5-O-isopropylidene-D-erythro-hexonate; (4R-CIS)-6-[(ACETYLOXY)METHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETIC ACID,T-BUTYL ESTER; rosuvastatin interMediates D-5; tert-butyl 2-{(4R,6S)-2,2-dimethyl-6-[(methyl-carbonyloxy)methyl]-1,3-dioxan-4-yl} acetate; 2-[(4R,6S)-6-(Acetoxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert-buthyl ester; (4R-Cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-aceticacid,1,1-dimethylethylester

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 353.1±22.0 °C at 760 mmHg
• 分子式: C₁₅H₂₆O₆
• 分子量: 302.363
• 闪点: 150.3±22.4 °C
• 精确质量: 302.172943
• PSA: 71.06000
• LogP: 2.18
• 外观性状: 白色或灰白色固体粉末
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.436
• 储存条件: 2-8°C

安全

• 危害码 (欧洲): Xi
• 海关编码: 2932999099

合成路线

127-08-2 154026-94-5 ~78% 154026-95-6

文献：DSM IP ASSESTS B.V. Patent: WO2003/106447 A1, 2003 ; Location in patent: Page 5 ;

10534-59-5 154026-94-5 ~99% 154026-95-6

文献：BAKHU PHARMA LIMITED; PROCTOR, Lee David; GREIG, Stuart Alexander James Patent: WO2012/17242 A1, 2012 ; Location in patent: Page/Page column 20 ;

127-08-2 143314-17-4 154026-94-5 ~% 154026-95-6

文献：WO2012/17242 A1, ; Page/Page column 14 ;

124655-09-0 75-36-5 ~% 154026-95-6

文献：Fan, Weizheng; Li, Wanfang; Ma, Xin; Tao, Xiaoming; Li, Xiaoming; Yao, Ying; Xie, Xiaomin; Zhang, Zhaoguo Journal of Organic Chemistry, 2011 , vol. 76, # 22 p. 9444 - 9451

143314-17-4 154026-94-5 ~% 154026-95-6

文献：WO2012/17242 A1, ; Page/Page column 11-12 ;

上下游产品

上游产品  6
127-08-2 154026-94-5 10534-59-5 143314-17-4
124655-09-0 75-36-5
下游产品  1
124655-09-0

海关

海关编码	2932999099
中文概述	2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%