76880-22-3

• 常用中文名：(E)-3-[4-(2-chlorophenyl)piperazin-1-yl]-1-(4-fluorophenyl)-2-methyl-prop-2-en-1-one
• 常用英文名：(E)-3-[4-(2-chlorophenyl)piperazin-1-yl]-1-(4-fluorophenyl)-2-methyl-prop-2-en-1-one
• CAS号：76880-22-3
• 分子式：C₂₀H₂₀ClFN₂O
• 分子量：358.83700
• 发布时间：2016-03-22 22:04:54
• 更新时间：2024-04-03 18:34:07

名称

• 英文名: (E)-3-[4-(2-chlorophenyl)piperazin-1-yl]-1-(4-fluorophenyl)-2-methylprop-2-en-1-one
• 英文别名: 2-Propen-1-one,3-(4-(2-chlorophenyl)-1-piperazinyl)-1-(4-fluorophenyl)-2-methyl; 3-[4-(2-chlorophenyl)piperazin-1-yl]-1-(4-fluorophenyl)-2-methylprop-2-en-1-one; 3-(4-(2-Chlorophenyl)-1-piperazinyl)-1-(4-fluorophenyl)-2-methyl-2-propen-1-one

物化性质

• 密度: 1.279g/cm3
• 沸点: 492.8ºC at 760 mmHg
• 分子式: C₂₀H₂₀ClFN₂O
• 分子量: 358.83700
• 闪点: 251.8ºC
• 精确质量: 358.12500
• PSA: 23.55000
• LogP: 4.39070
• 折射率: 1.632

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UD5573000 CHEMICAL NAME : 2-Propen-1-one, 3-(4-(2-chlorophenyl)-1-piperazinyl)-1-(4-fluoropheny l)-2-methyl- CAS REGISTRY NUMBER : 76880-22-3 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C20-H20-Cl-F-N2-O MOLECULAR WEIGHT : 358.87 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 800 mg/kg TOXIC EFFECTS : Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation REFERENCE : IJSBDB Indian Journal of Chemistry, Section B: Organic Chemistry, Including Medicinal Chemistry. (Publications & Information Directorate, Council of Scientific and Industrial Research (CSIR), Hillside Rd., New Delhi 110 012, India) V.14B- 1976- Volume(issue)/page/year: 19,695,1980

合成路线

39512-50-0 65201-51-6 ~% 76880-22-3

文献：Pratap, Ram; Gupta, R. C.; Srimal, R. C.; Anand, Nitya Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 8 p. 695 - 698

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