61047-43-6

• 常用中文名：8-溴-2-甲基喹啉
• 常用英文名：8-Bromo-2-methylquinoline
• CAS号：61047-43-6
• 分子式：C₁₀H₈BrN
• 分子量：222.081
• 相关类别： 医药中间体 杂环化合物 喹啉类化合物
• 发布时间：2018-07-15 18:14:54
• 更新时间：2024-01-10 18:48:06

名称

• 中文名: 8-溴-2-甲基喹啉
• 英文名: 8-Bromo-2-methylquinoline
• 中文别名: 8-溴喹哪啶
• 英文别名: 8-Bromo-2-methylquinoline; Quinoline, 8-bromo-2-methyl-

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 299.7±20.0 °C at 760 mmHg
• 熔点: 63-65ºC
• 分子式: C₁₀H₈BrN
• 分子量: 222.081
• 闪点: 135.0±21.8 °C
• 精确质量: 220.984009
• PSA: 12.89000
• LogP: 2.97
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.654
• 储存条件: 室温

MSDS

Section I.Chemical Product and Company Identification Chemical Name 8-Bromo-2-methylquinoline Portland OR SynonymQuinoline, 8-bromo-2-methyl- (CA INDEX NAME); 8-Bromoquinaldine Chemical FormulaC10H8BrN CAS Number61047-43-6 Section II.Composition and Information on Ingredients Toxicology Data Chemical NameCAS Number Percent (%)TLV/PEL Min. 98.0 (GC, Not available.Not available. 8-Bromo-2-methylquinoline61047-43-6 T) Section III. Hazards Identification Acute Health EffectsIrritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound. Chronic Health EffectsCARCINOGENIC EFFECTS : Not available. MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions. Section IV.First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention. Skin ContactIn case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or Inhalation waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not improve. INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat. Ingestion Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Section V.Fire and Explosion Data Not available. May be combustible at high temperature.Auto-Ignition Flammability Flash PointsFlammable LimitsNot available. Not available. These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NOx), halogenated compounds. Combustion Products Fire HazardsNot available. Risks of explosion of the product in presence of mechanical impact: Not available. Explosion Hazards Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet. and Instructions Consult with local fire authorities before attempting large scale fire-fighting operations. Continued on Next Page 8-Bromo-2-methylquinoline Section VI.Accidental Release Measures Spill CleanupIrritating material. Use a shovel to put the material into a convenient waste disposal container. Consult federal, state, and/or local authorities for Instructions assistance on disposal. Section VII. Handling and Storage Handling and StorageIRRITANT. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool place. Avoid excessive heat and light. Do not breathe dust. Information Section VIII. Exposure Controls/Personal Protection Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended Engineering Controls exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Splash goggles. Lab coat. Dust respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a Personal Protection specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent. Exposure LimitsNot available. Section IX. Physical and Chemical Properties Physical state @ 20°CSolid. (Crystal, powder. White, slightlySolubility Not available. pale yellow.) Not available. Specific Gravity Molecular Weight222.08Partition CoefficientNot available. Boiling Point132°C (269.6°F) @ 0.1 mmHgVapor PressureNot applicable. Melting Point68°C (154.4°F)Vapor DensityNot available. Not available.Not available. Refractive IndexVolatility Critical TemperatureNot available.OdorNot available. Not available.Not available. ViscosityTaste Section X.Stability and Reactivity Data Stability This material is stable if stored under proper conditions. (See Section VII for instructions) Conditions of InstabilityAvoid excessive heat and light. IncompatibilitiesNot available. Section XI. Toxicological Information RTECS NumberNot available. Eye Contact. Ingestion. Inhalation. Routes of Exposure Not available. Toxicity Data CARCINOGENIC EFFECTS : Not available. Chronic Toxic Effects MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions. Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye Acute Toxic Effects is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound. Section XII.Ecological Information EcotoxicityNot available. Not available. Environmental Fate Continued on Next Page 8-Bromo-2-methylquinoline Section XIII. Disposal Considerations Waste DisposalRecycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. Section XIV. Transport Information Not a DOT controlled material (United States). DOT Classification PIN NumberNot applicable. Proper Shipping NameNot applicable. Packing Group (PG)Not applicable. DOT Pictograms Section XV. Other Regulatory Information and Pictograms TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40 CFR 720.36 (C) for those products not on the inventory list: (EPA) (i) These products are supplied solely for use in research and development by or under the supervision of a technically qualified individual as defined in 40 CFR 720.0 et sec. (ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be supplied on an MSDS sheet. WHMIS ClassificationNot available. (Canada) EINECS Number (EEC)Not available. EEC Risk StatementsR36/37/38- Irritating to eyes, respiratory system and skin. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933499090

合成路线

615-36-1 123-73-9 ~52% 61047-43-6

文献：SIRTRIS PHARMACEUTICALS, INC.; VU, Chi, B.; CASAUBON, Rebecca, L. Patent: WO2010/101949 A1, 2010 ; Location in patent: Page/Page column 116; 117 ; WO 2010/101949 A1

871507-79-8 594-27-4 ~45% 61047-43-6 1463-17-8

文献：Journal of Medicinal Chemistry, , vol. 52, # 3 p. 868 - 877

1336-21-6 123-73-9 615-36-1 ~% 61047-43-6

文献：US2007/274922 A1, ;

123-73-9 615-36-1 ~% 61047-43-6

文献：Lord, Anna-Marie; Mahon, Mary F.; Lloyd, Matthew D.; Threadgill, Michael D. Journal of Medicinal Chemistry, 2009 , vol. 52, # 3 p. 868 - 877

上下游产品

上游产品  5
615-36-1 123-73-9 871507-79-8 594-27-4
1336-21-6
下游产品  4
864779-05-5 847861-97-6 904886-25-5 914208-15-4

海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%