90729-41-2

• 常用中文名：奥索地平
• 常用英文名：Oxodipine
• CAS号：90729-41-2
• 分子式：C₁₉H₂₁NO₆
• 分子量：359.37300
• 发布时间：2018-06-03 08:00:00
• 更新时间：2024-01-19 11:39:08

名称

• 中文名: 奥索地平
• 英文名: 5-O-ethyl 3-O-methyl 4-(1,3-benzodioxol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• 英文别名: Oxodipinum; IQB-837-V; Oxodipino [Spanish]; Oxodipinum [Latin]; Oxodipine [INN]; 3,5-Pyridinedicarboxylic acid,1,4-dihydro-4-(1,3-benzodioxol-4-yl)-2,6-dimethyl-,ethyl methyl ester; Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(2,3-(methylenedioxy)phenyl)-3,5-pyridinedicarboxylate; OXODIPINE; Oxodipino

物化性质

• 密度: 1.247g/cm3
• 沸点: 470ºC at 760 mmHg
• 分子式: C₁₉H₂₁NO₆
• 分子量: 359.37300
• 闪点: 238ºC
• 精确质量: 359.13700
• PSA: 83.09000
• LogP: 2.71500
• 折射率: 1.552

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : US7968500 CHEMICAL NAME : 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(1,3-benzodioxol-4-yl)-2,6-dimethyl-, ethyl methyl ester CAS REGISTRY NUMBER : 90729-41-2 LAST UPDATED : 199406 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C19-H21-N-O6 MOLECULAR WEIGHT : 359.41 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,633,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 54(2),40,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 2160 mg/kg/13W-I TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section Endocrine - other changes Endocrine - changes in adrenal weight REFERENCE : TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 20,549,1992