158144-79-7

• 常用中文名：1-BOC-4-氰基-4-苯基哌啶
• 常用英文名：tert-butyl 4-cyano-4-phenylpiperidine-1-carboxylate
• CAS号：158144-79-7
• 分子式：C₁₇H₂₂N₂O₂
• 分子量：286.369
• 发布时间：2018-06-26 11:27:39
• 更新时间：2024-07-18 10:32:45

名称

• 中文名: 4-氰基-4-苯基哌啶-1-羧酸叔丁酯
• 英文名: tert-butyl 4-cyano-4-phenylpiperidine-1-carboxylate
• 中文别名: 1-BOC-4-氰基-4-苯基哌啶; 2-甲基-2-丙基4-氰基-4-苯基-1-哌啶羧酸酯
• 英文别名: 1-N-BOC-4-PHENYLPIPERIDINE-4-CARBONITRILE; 1-Boc-4-phenyl-4-piperidinecarbonitrile; 2-Methyl-2-propanyl 4-cyano-4-phenyl-1-piperidinecarboxylate; Tert-butyl 4-cyano-4-phenyl-piperidine-1-carboxylate; TERT-BUTYL 4-CYANO-4-PHENYL-1-PIPERIDINECARBOXYLATE; 1-Piperidinecarboxylic acid, 4-cyano-4-phenyl-, 1,1-dimethylethyl ester; N-(tert-butoxycarbonyl)-4-phenyl-4-cyanopiperidine; 1-Boc-4-cyano-4-phenylpiperidine; 4-cyano-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester; MFCD09056769

物化性质

• 密度: 1.119g/cm3
• 沸点: 426.047°C at 760 mmHg
• 分子式: C₁₇H₂₂N₂O₂
• 分子量: 286.369
• 闪点: 211.5±28.7 °C
• 精确质量: 286.168121
• PSA: 53.33000
• LogP: 2.69
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.549

合成路线

40481-13-8 24424-99-5 ~99% 158144-79-7

文献：BRISTOL-MYERS SQUIBB COMPANY Patent: WO2008/124757 A1, 2008 ; Location in patent: Page/Page column 51-52 ; WO 2008/124757 A1

24424-99-5 51304-58-6 ~96% 158144-79-7

文献：Duan, Maosheng; Aquino, Christopher; Ferris, Robert; Kazmierski, Wieslaw M.; Kenakin, Terry; Koble, Cecilia; Wheelan, Pat; Watson, Chris; Youngman, Michael Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 6 p. 1610 - 1613

34619-03-9 51304-58-6 ~10% 158144-79-7

文献：SMITHKLINE BEECHAM CORPORATION Patent: WO2004/54974 A2, 2004 ; Location in patent: Page 48 ; WO 2004/054974 A2

140-29-4 118753-70-1 ~% 158144-79-7

文献：Kuduk, Scott D.; Chang, Ronald K.; Di Marco, Christina N.; Pitts, Daniel R.; Greshock, Thomas J.; Ma, Lei; Wittmann, Marion; Seager, Matthew A.; Koeplinger, Kenneth A.; Thompson, Charles D.; Hartman, George D.; Bilodeau, Mark T.; Ray, William J. Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4773 - 4780