依福地平

更新时间：2024-01-03 19:31:44

依福地平结构式	常用名	依福地平	英文名	Efonidipine
	CAS号	111011-63-3	分子量	631.655
	密度	1.3±0.1 g/cm3	沸点	746.9±60.0 °C at 760 mmHg
	分子式	C₃₄H₃₈N₃O₇P	熔点	N/A
	MSDS	N/A	闪点	405.5±32.9 °C

依福地平用途

Efonidipine(NZ-105)是T型和L型钙离子通道双重阻断剂。

中文名	依福地平
英文名	2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
英文别名	更多

描述	Efonidipine(NZ-105)是T型和L型钙离子通道双重阻断剂。
相关类别	信号通路 >> 跨膜转运 >> 钙通道研究领域 >> 心血管疾病
参考文献	[1]. Ikeda K, et al. Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells. Tohoku J Exp Med. 2011;224(4):263-71. [2]. Nakano N, et al. Effects of efonidipine, an L- and T-type calcium channel blocker, on the renin-angiotensin-aldosterone system in chronic hemodialysis patients. Int Heart J. 2010 May;51(3):188-92. [3]. Suzuki S, et al. Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters. Circ J. 2007 Dec;71(12):1970-6. [4]. Lee TS, et al. Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20.

描述

Efonidipine(NZ-105)是T型和L型钙离子通道双重阻断剂。

相关类别

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 心血管疾病

参考文献

[1]. Ikeda K, et al. Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells. Tohoku J Exp Med. 2011;224(4):263-71.

[2]. Nakano N, et al. Effects of efonidipine, an L- and T-type calcium channel blocker, on the renin-angiotensin-aldosterone system in chronic hemodialysis patients. Int Heart J. 2010 May;51(3):188-92.

[3]. Suzuki S, et al. Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters. Circ J. 2007 Dec;71(12):1970-6.

[4]. Lee TS, et al. Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20.

密度	1.3±0.1 g/cm3
沸点	746.9±60.0 °C at 760 mmHg
分子式	C₃₄H₃₈N₃O₇P
分子量	631.655
闪点	405.5±32.9 °C
精确质量	631.244751
PSA	132.73000
LogP	6.99
外观性状	粉末
蒸汽压	0.0±2.5 mmHg at 25°C
折射率	1.625
储存条件	-20℃

2-methoxy-5,5-d...

1005-69-2

依福地平

111011-63-3

文献：Chemical and Pharmaceutical Bulletin, , vol. 40, # 9 p. 2362 - 2369

2-acetonyl-5,5-...

111011-80-4

依福地平

111011-63-3

文献：Chemical and Pharmaceutical Bulletin, , vol. 40, # 9 p. 2362 - 2369

新戊二醇(NPG)

126-30-7

依福地平

111011-63-3

文献：Chemical and Pharmaceutical Bulletin, , vol. 40, # 9 p. 2362 - 2369

依福地平上游产品 3
CAS号1005-69-2 2-methoxy-5,5-d... CAS号111011-80-4 2-acetonyl-5,5-... CAS号126-30-7 新戊二醇(NPG)
依福地平下游产品 0

3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, (4S)-

2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate

Efonidipine HCl

3-(benzyl-(phenyl)amino)ethyl-5-(5,5-dimethyl-2-oxo-1,3-dioxaphosphorinane-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine

2-[Benzyl(phenyl)amino]ethyl (4S)-5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylate

Efonidipine [INN]

Efonidipine