UNC0224

• 常用名: UNC0224
• 英文名: UNC 0224
• CAS号: 1197196-48-7
• 分子量: 485.665
• 密度: 1.1±0.1 g/cm3
• 沸点: 641.0±65.0 °C at 760 mmHg
• 分子式: C₂₆H₄₃N₇O₂
• 熔点: N/A
• 闪点: 341.5±34.3 °C

UNC0224用途

UNC0224是G9a抑制剂，IC50为15 nM。

UNC0224名称

• 中文名: UNC0224
• 英文名: 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

UNC0224生物活性

• 描述: UNC0224是G9a抑制剂,IC50为15 nM。
• 相关类别:
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Liu F, et al. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J Med Chem. 2009 Dec 24;52(24):7950-3.

  [2]. Liu F, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57.

UNC0224物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 641.0±65.0 °C at 760 mmHg
• 分子式: C₂₆H₄₃N₇O₂
• 分子量: 485.665
• 闪点: 341.5±34.3 °C
• 精确质量: 485.347809
• PSA: 69.23000
• LogP: 1.30
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.589
• 储存条件: 2-8℃

UNC0224英文别名

• 7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
• 4-quinazolinamine, 7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-
• 7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
• unc0224
• UNC-0224