RSL3 1S,3R-

• 常用名: RSL3 1S,3R-
• 英文名: RSL3
• CAS号: 1219810-16-8
• 分子量: 440.876
• 密度: 1.4±0.1 g/cm3
• 沸点: 641.3±55.0 °C at 760 mmHg
• 分子式: C₂₃H₂₁ClN₂O₅
• 熔点: N/A
• 闪点: 341.6±31.5 °C

RSL3 1S,3R-用途

RSL3 是GSH过氧化物酶4的抑制剂，能够抑制半胱氨酸和 谷氨酸酯转运蛋白，能够阻碍GSH的合成，IC50 值是100 nM.

RSL3 1S,3R-名称

• 中文名: RSL3 1S,3R-
• 英文名: Methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate

RSL3 1S,3R-生物活性

• 描述: RSL3 (1S,3R-) 是一种谷胱甘肽过氧化物酶4 (GPX4) 抑制剂,在细胞试验中EC50 为10 μM。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Christina Schott et al. Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death.Front Oncol. 2015, 5: 131.

  [2]. Michel Weiwer et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorganic & Medicinal Chemistry Letters 22 (2012) 1822-1826.

  [3]. Wan Seok Yang et al. Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells. Chem Biol, 2008 Mar, 15(3): 234-245.

RSL3 1S,3R-物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 641.3±55.0 °C at 760 mmHg
• 分子式: C₂₃H₂₁ClN₂O₅
• 分子量: 440.876
• 闪点: 341.6±31.5 °C
• 精确质量: 440.113892
• LogP: 3.07
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.636
• 储存条件: 2-8°C

RSL3 1S,3R-英文别名

• 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-, methyl ester, (1S,3R)-
• Methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate
• RSL3
• RSL3 (1S,3R-)