Tetrazine-Ph-NHCO-C3-NHS ester
Tetrazine-Ph-NHCO-C3-NHS ester结构式
|
常用名 | Tetrazine-Ph-NHCO-C3-NHS ester | 英文名 | Tetrazine-Ph-NHCO-C3-NHS ester |
|---|---|---|---|---|
| CAS号 | 1244040-64-9 | 分子量 | 398.37300 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C18H18N6O5 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
Tetrazine-Ph-NHCO-C3-NHS ester用途Tetrazine-Ph-NHCO-C3-NHS ester 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。 |
| 英文名 | 2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate |
|---|
| 描述 | Tetrazine-Ph-NHCO-C3-NHS ester 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。 |
|---|---|
| 相关类别 | |
| 靶点 |
PEGs |
| 体外研究 | PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。 |
| 参考文献 |
| 分子式 | C18H18N6O5 |
|---|---|
| 分子量 | 398.37300 |
| 精确质量 | 398.13400 |
| PSA | 144.34000 |
| LogP | 0.65610 |
| 储存条件 | 2-8°C，密封，干燥 |
|
Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation.
Bioconjug. Chem. 22 , 2263-2270, (2011) 1,2,4,5-Tetrazines have been established as effective dienes for inverse electron demand [4 + 2] Diels-Alder cycloaddition reactions with strained alkenes for over 50 years. Recently, this reaction pa... |
|
|
Tetrazine-based cycloadditions: application to pretargeted live cell imaging.
Bioconjug. Chem. 19 , 2297-2299, (2008) Bioorthogonal tetrazine cycloadditions have been applied to live cell labeling. Tetrazines react irreversibly with the strained dienophile norbornene forming dihydropyrazine products and dinitrogen. T... |
|
|
Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.
J. Am. Chem. Soc. 130 , 13518-13519, (2008) Described is a bioorthogonal reaction that proceeds with unusually fast reaction rates without need for catalysis: the cycloaddition of s-tetrazine and trans-cyclooctene derivatives. The reactions tol... |
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：Tetrazine-Ph-NHCO-C3-NHS ester
- 纯度：98.0%
- 规格：
- 联系人：徐经理
- 联系电话：13311869306
查看所有供应商和价格请点击：