Imigliptin dihydrochloride

• 常用名: Imigliptin dihydrochloride
• 英文名: Imigliptin dihydrochloride
• CAS号: 1314944-07-4
• 分子量: 376.455
• 密度: 1.3±0.1 g/cm3
• 沸点: 595.3±50.0 °C at 760 mmHg
• 分子式: C₂₁H₂₆Cl₂N₆O
• 熔点: N/A
• 闪点: 313.8±30.1 °C

Imigliptin dihydrochloride用途

一种新型有效,选择性,口服DPP-4抑制剂,IC50为9 nM；对DPP-8和DPP-9无活性(IC50>100 uM)；对低葡萄糖水平的db/db小鼠有很强的作用,降低口服葡萄糖耐量的AUC,降低TG和HbA1c水平,保护β细胞。糖尿病2期临床

Imigliptin dihydrochloride名称

• 英文名: Imigliptin

Imigliptin dihydrochloride生物活性

• 描述: 一种新型有效,选择性,口服DPP-4抑制剂,IC50为9 nM；对DPP-8和DPP-9无活性(IC50>100 uM)；对低葡萄糖水平的db/db小鼠有很强的作用,降低口服葡萄糖耐量的AUC,降低TG和HbA1c水平,保护β细胞。糖尿病2期临床
• 参考文献: References 1. Shu C, et al. ACS Med Chem Lett. 2014 Jun 16;5(8):921-6. 2. Liu D, et al. Eur J Pharm Sci. 2016 Jun 30;89:73-82. View Related Products by Target Dipeptidyl Peptidase (DPP) Diabetes

Imigliptin dihydrochloride物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 595.3±50.0 °C at 760 mmHg
• 分子式: C₂₁H₂₆Cl₂N₆O
• 分子量: 376.455
• 闪点: 313.8±30.1 °C
• 精确质量: 376.201172
• LogP: 1.33
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.685

Imigliptin dihydrochloride英文别名

• 2-({7-[(3R)-3-Amino-1-piperidinyl]-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl}methyl)benzonitrile
• Benzonitrile, 2-[[7-[(3R)-3-amino-1-piperidinyl]-2,3-dihydro-3,5-dimethyl-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl]methyl]-
• Imigliptin