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环氧酶素

更新时间:2024-01-13 20:36:13

环氧酶素结构式
环氧酶素结构式
品牌特惠专场
常用名 环氧酶素 英文名 Epoxomicin
CAS号 134381-21-8 分子量 554.719
密度 1.1±0.1 g/cm3 沸点 795.7±60.0 °C at 760 mmHg
分子式 C28H50N4O7 熔点 107-109ºC
MSDS 中文版 美版 闪点 435.0±32.9 °C

 环氧酶素用途


Epoxomicin(BU-4061T)是从放线菌中分离出的抗肿瘤化合物,是20S蛋白酶体的选择不可逆抑制剂。

 环氧酶素名称

中文名 N-乙酰基-N-甲基-L-异亮氨酰-L-异亮氨酰-N-[(1S)-3-甲基-1-[[(2R)-2-甲基-2-环氧乙烷基]羰基]丁基]-L-苏氨酰胺
英文名 Epoxomicin
英文别名 更多

 环氧酶素物理化学性质

密度 1.1±0.1 g/cm3
沸点 795.7±60.0 °C at 760 mmHg
熔点 107-109ºC
分子式 C28H50N4O7
分子量 554.719
闪点 435.0±32.9 °C
精确质量 554.367920
PSA 157.44000
LogP 3.32
外观性状 白色至灰白色固体
蒸汽压 0.0±6.3 mmHg at 25°C
折射率 1.504
储存条件 -20°C

 环氧酶素安全信息

个人防护装备 Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码 NONH for all modes of transport

 环氧酶素文献13

更多文献
Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain.

Biochim. Biophys. Acta 1853(1) , 183-91, (2015)

In mammalian cells the nuclear-encoded subunits of complex I are imported into mitochondria, where they are assembled with mt-DNA encoded subunits in the complex, or exchanged with pre-existing copies...

Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells.

J. Biol. Chem. 285 , 13092-106, (2010)

Carriers of mutations in the cell cycle checkpoint protein kinase ataxia telangiectasia mutated (ATM), which represent 1-2% of the general population, have an increased risk of breast cancer. However,...

The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.

Biochem. J. 456(2) , 173-84, (2013)

The ubiquitin-proteasome system is important to maintain pancreatic β-cell function. Inhibition of the proteasome significantly reduced glucose-induced insulin secretion. Key regulators of the stimulu...

 环氧酶素英文别名

S7038,BU-4061T
Epoxomicin (BU-4061T)
(2S,3S)-2-[[(2S,3S)-2-[acetyl(methyl)amino]-3-methylpentanoyl]amino]-N-[(2S,3R)-3-hydroxy-2-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]butanoyl]-3-methylpentanamide
Epoxomicin
N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-1-oxo-2-pentanyl}-L-threoninamide
L-Threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-
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