环氧酶素结构式
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常用名 | 环氧酶素 | 英文名 | Epoxomicin |
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CAS号 | 134381-21-8 | 分子量 | 554.719 | |
密度 | 1.1±0.1 g/cm3 | 沸点 | 795.7±60.0 °C at 760 mmHg | |
分子式 | C28H50N4O7 | 熔点 | 107-109ºC | |
MSDS | 中文版 美版 | 闪点 | 435.0±32.9 °C |
环氧酶素用途Epoxomicin(BU-4061T)是从放线菌中分离出的抗肿瘤化合物,是20S蛋白酶体的选择不可逆抑制剂。 |
中文名 | N-乙酰基-N-甲基-L-异亮氨酰-L-异亮氨酰-N-[(1S)-3-甲基-1-[[(2R)-2-甲基-2-环氧乙烷基]羰基]丁基]-L-苏氨酰胺 |
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英文名 | Epoxomicin |
英文别名 | 更多 |
描述 | Epoxomicin是一种可渗透细胞且不可逆的蛋白酶体抑制剂,主要抑制胰凝乳蛋白酶样活性。 |
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相关类别 | |
参考文献 |
密度 | 1.1±0.1 g/cm3 |
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沸点 | 795.7±60.0 °C at 760 mmHg |
熔点 | 107-109ºC |
分子式 | C28H50N4O7 |
分子量 | 554.719 |
闪点 | 435.0±32.9 °C |
精确质量 | 554.367920 |
PSA | 157.44000 |
LogP | 3.32 |
外观性状 | 白色至灰白色固体 |
蒸汽压 | 0.0±6.3 mmHg at 25°C |
折射率 | 1.504 |
储存条件 | -20°C |
个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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危险品运输编码 | NONH for all modes of transport |
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Biochim. Biophys. Acta 1853(1) , 183-91, (2015) In mammalian cells the nuclear-encoded subunits of complex I are imported into mitochondria, where they are assembled with mt-DNA encoded subunits in the complex, or exchanged with pre-existing copies... |
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Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells.
J. Biol. Chem. 285 , 13092-106, (2010) Carriers of mutations in the cell cycle checkpoint protein kinase ataxia telangiectasia mutated (ATM), which represent 1-2% of the general population, have an increased risk of breast cancer. However,... |
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The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.
Biochem. J. 456(2) , 173-84, (2013) The ubiquitin-proteasome system is important to maintain pancreatic β-cell function. Inhibition of the proteasome significantly reduced glucose-induced insulin secretion. Key regulators of the stimulu... |
S7038,BU-4061T |
Epoxomicin (BU-4061T) |
(2S,3S)-2-[[(2S,3S)-2-[acetyl(methyl)amino]-3-methylpentanoyl]amino]-N-[(2S,3R)-3-hydroxy-2-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]butanoyl]-3-methylpentanamide |
Epoxomicin |
N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-1-oxo-2-pentanyl}-L-threoninamide |
L-Threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]- |