M-110

• 常用名: M-110
• 英文名: M-110
• CAS号: 1395048-49-3
• 分子量: 445.94
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₂H₂₈ClN₅O₃
• 熔点: N/A
• 闪点: N/A

M-110用途

M-110是Pim激酶抑制剂，抑制前列腺癌细胞系增殖IC50为0.6-0.9uM。

M-110名称

• 中文名: M-110
• 英文名: M-110

M-110生物活性

• 描述: M-110是Pim激酶抑制剂,抑制前列腺癌细胞系增殖IC50为0.6-0.9uM。
• 相关类别:
  信号通路 >> JAK/STAT信号通路 >> 皮姆
  研究领域 >> 癌症
• 参考文献:

  [1]. He Y, et al. Schisantherin A suppresses osteoclast formation and wear particle-induced osteolysis via modulating RANKL signaling pathways. Biochem Biophys Res Commun. 2014 Jul 4;449(3):344-50.

  [2]. Zhou E, et al. Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-κB and MAPKs signaling pathways. Int Immunopharmacol. 2014 Sep;22(1):133-40.

  [3]. Sa F, et al. Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo. Neurosci Lett. 2015 Apr 23;593:7-12.

  [4]. Zhang LQ, et al. Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways. J Ethnopharmacol. 2015 Apr 29. pii: S0378-8741(15)00306-2.

M-110物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₂H₂₈ClN₅O₃
• 分子量: 445.94
• 精确质量: 445.188080
• LogP: 4.08
• 折射率: 1.623
• 储存条件: 2-8°C

M-110安全信息

• 危险品运输编码: NONH for all modes of transport

M-110英文别名

• 4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[(1E)-1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
• MFCD28053523
• N'-[(1E)-1-(4-Chloro-2-hydroxyphenyl)propylidene]-2-{[3-(4-morpholinyl)propyl]amino}isonicotinohydrazide