西洛司特

• 常用名: 西洛司特
• 英文名: Cilomilast
• CAS号: 153259-65-5
• 分子量: 343.417
• 密度: 1.2±0.1 g/cm3
• 沸点: 549.1±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₅NO₄
• 熔点: 157ºC
• 闪点: 285.9±30.1 °C

西洛司特用途

Cilomilast(SB 207499; Ariflo)是PDE4抑制剂,IC50为110 nM,有抗炎活性。

西洛司特名称

• 中文名: 西洛司特
• 英文名: 4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic acid
• 中文别名: 替吡法尼 | 4-氰基-4-(3-环戊氧基-4-甲氧基苯基)环己烷-1-甲酸

西洛司特生物活性

• 描述: Cilomilast(SB 207499; Ariflo)是PDE4抑制剂,IC50为110 nM,有抗炎活性。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. MARY S. BARNETTE et al. SB 207499 (Ariflo), a Potent and Selective Second-Generation Phosphodiesterase 4 Inhibitor: In Vitro Anti-inflammatory Actions JPET 284:420 -426, 1998

  [2]. Munisso MC, Kang JH, Tsurufuji M, Yamaoka T.Cilomilast enhances osteoblast differentiation of mesenchymal stem cells and bone formation induced by bone morphogenetic protein 2.Biochimie. 2012 Jun 15.

  [3]. Sadrai Z, Stevenson W, Okanobo A, Chen Y, Dohlman TH, Hua J, Amparo F, Chauhan SK, Dana R.PDE4 inhibition suppresses IL-17-associated immunity in dry eye disease.Invest Ophthalmol Vis Sci. 2012 Jun 14;53(7):3584-91. Print 2012 Jun.

  [4]. Pace E, Ferraro M, Uasuf CG, Giarratano A, La Grutta S, Liotta G, Johnson M, Gjomarkaj M.Cilomilast counteracts the effects of cigarette smoke in airway epithelial cells.Cell Immunol. 2011;268(1):47-53. Epub 2011 Feb 20.

  [5]. Barton AK, Niedorf F, Gruber AD, Kietzmann M, Ohnesorge B.Pharmacological studies of bronchial constriction inhibited by parasympatholytics and cilomilast using equine precision-cut lung slices.Berl Munch Tierarztl Wochenschr. 2010 May-Jun;123(5-6):229-35

西洛司特物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 549.1±50.0 °C at 760 mmHg
• 熔点: 157ºC
• 分子式: C₂₀H₂₅NO₄
• 分子量: 343.417
• 闪点: 285.9±30.1 °C
• 精确质量: 343.178345
• PSA: 79.55000
• LogP: 3.30
• 外观性状: 白色固体
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.568
• 储存条件: ?20°C
• 水溶解性: DMSO: soluble15mg/mL, clear

西洛司特MSDS

西洛司特MSDS英文版

西洛司特安全信息

• 危险品运输编码: NONH for all modes of transport

西洛司特英文别名

• cis-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-4-cyanocyclohexane-1-carboxylic acid
• Cyclohexanecarboxylic acid, 4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, cis-
• 1xlx
• Cyclohexanecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, cis-
• cis-4-Cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexanecarboxylic acid
• cis-4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylic acid
• S1455_Selleck
• Ariflo
• Cyclohexanecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
• c-4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)-r-1-cyclohexane carboxylic acid
• 1xom
• cilomilast
• 4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylic acid
• SB-207499