2-(2-呋喃基)-7-(2-苯基乙基)-7H-吡唑并[4,3-e][1,2,4]噻唑并[1,5-c]嘧啶-5-胺

更新时间：2024-01-08 17:33:44

2-(2-呋喃基)-7-(2-苯基乙基)-7H-吡唑并[4,3-e][1,2,4]噻唑并[1,5-c]嘧啶-5-胺结构式	常用名	2-(2-呋喃基)-7-(2-苯基乙基)-7H-吡唑并[4,3-e][1,2,4]噻唑并[1,5-c]嘧啶-5-胺	英文名	SCH 58261
	CAS号	160098-96-4	分子量	345.35800
	密度	1.54g/cm3	沸点	N/A
	分子式	C₁₈H₁₅N₇O	熔点	N/A
	MSDS	美版	闪点	N/A

用途

SCH58261是adenosine A2A receptor竞争性的拮抗剂。

中文名	2-(2-呋喃基)-7-(2-苯基乙基)-7H-吡唑并[4,3-e][1,2,4]噻唑并[1,5-c]嘧啶-5-胺
英文名	2-(2-furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
英文别名	更多

描述	SCH58261是adenosine A2A receptor竞争性的拮抗剂。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体研究领域 >> 癌症
参考文献	[1]. Paul A. Beavis et al. Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors. Proc Natl Acad Sci U S A, 2013 Sep 3, 110(36): 14711-14716. [2]. Alessia Melani et al. Time-course of protection by the selective A2Areceptor antagonist SCH58261 after transient focal cerebral ischemia. Neurological Sciences, August 2015, Volume 36, Issue 8, pp 1441-1448. [3]. Varani K et al. Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 binding. Br J Pharmacol, 1996 Apr;117(8):1693-701.

描述

SCH58261是adenosine A2A receptor竞争性的拮抗剂。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

研究领域 >> 癌症

参考文献

[1]. Paul A. Beavis et al. Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors. Proc Natl Acad Sci U S A, 2013 Sep 3, 110(36): 14711-14716.

[2]. Alessia Melani et al. Time-course of protection by the selective A2Areceptor antagonist SCH58261 after transient focal cerebral ischemia. Neurological Sciences, August 2015, Volume 36, Issue 8, pp 1441-1448.

[3]. Varani K et al. Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 binding. Br J Pharmacol, 1996 Apr;117(8):1693-701.

密度	1.54g/cm3
分子式	C₁₈H₁₅N₇O
分子量	345.35800
精确质量	345.13400
PSA	100.06000
LogP	3.14010
折射率	1.807
储存条件	2-8°C

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
海关编码	2934999090

氰胺

420-04-2

5-amino-1-(β-ph...

159979-95-0

~20%

2-(2-呋喃基)-7-(2-...

160098-96-4

文献：Baraldi, Pier Giovanni; Cacciari, Barbara; Spalluto, Giampiero; Pineda De Las Infantas Y Villatoro, Maria Jose; Zocchi, Cristina; Dionisotti, Silvio; Ongini, Ennio Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1164 - 1171

2-呋喃甲酰肼

3326-71-4

2-(2-呋喃基)-7-(2-...

160098-96-4

N-(4-imino-1-ph...

162401-28-7

2-(2-呋喃基)-7-(2-...

160098-96-4

未登录

159979-88-1

2-(2-呋喃基)-7-(2-...

160098-96-4

上游产品 3
CAS号420-04-2 氰胺 CAS号159979-95-0 5-amino-1-(β-ph... CAS号3326-71-4 2-呋喃甲酰肼
下游产品 0

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

On the role of adenosine (A)₂A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats.

Psychopharmacol. Ser. 232(2) , 421-35, (2015)

Several studies have suggested the inhibitory control of adenosine (A)2A receptor stimulation in cocaine-induced behavioral actions.A combination of systemic or local drug injections and in vivo neuro...

Endothelial dysfunction impairs vascular neurotransmission in tail arteries.

Neurochem. Int. 80 , 7-13, (2015)

The present study intends to clarify if endothelium dysfunction impairs vascular sympathetic neurotransmission. Electrically-evoked tritium overflow (100 pulses/5 Hz) was evaluated in arteries (intact...

Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure.

J. Neuroinflammation 12 , 115, (2015)

Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a degenerative disease characterized by the loss of retinal ganglion cells (RGCs). There is clinical and experimental evidence ...

7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine

2-(Furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine

SCH58261

SCH 58261