(S)-PFI 2 hydrochloride结构式
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常用名 | (S)-PFI 2 hydrochloride | 英文名 | (S)-PFI 2 hydrochloride |
|---|---|---|---|---|
| CAS号 | 1627607-88-8 | 分子量 | 535.982 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C23H26ClF4N3O3S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
(S)-PFI 2 hydrochloride用途Negative control of (R)-PFI 2 hydrochloride. Exhibits 500-fold lower activity in a SETD7 enzymatic assay (IC50 = 1 μM) compared to the active enantiomer. |
| 英文名 | 8-Fluoro-N-{(2S)-1-oxo-1-(1-pyrrolidinyl)-3-[3-(trifluoromethyl)phenyl]-2-propanyl}-1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride (1:1) |
|---|---|
| 英文别名 | 更多 |
| 分子式 | C23H26ClF4N3O3S |
|---|---|
| 分子量 | 535.982 |
| 精确质量 | 535.131958 |
| 储存条件 | -20°C，密闭，干燥 |
| 危险品运输编码 | NONH for all modes of transport |
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(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Proc. Natl. Acad. Sci. U. S. A. 111(35) , 12853-8, (2014) SET domain containing (lysine methyltransferase) 7 (SETD7) is implicated in multiple signaling and disease related pathways with a broad diversity of reported substrates. Here, we report the discovery... |
| 8-Fluoro-N-{(2S)-1-oxo-1-(1-pyrrolidinyl)-3-[3-(trifluoromethyl)phenyl]-2-propanyl}-1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride (1:1) |
| 6-Isoquinolinesulfonamide, 8-fluoro-1,2,3,4-tetrahydro-N-[(1S)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-, hydrochloride (1:1) |
| (S)-PFI-2 HCl |
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