DOTATATE

• 常用名: DOTATATE
• 英文名: DOTATATE
• CAS号: 177943-88-3
• 分子量: 1435.623
• 密度: 1.5±0.1 g/cm3
• 沸点: 1738.9±65.0 °C at 760 mmHg
• 分子式: C₆₅H₉₀N₁₄O₁₉S₂
• 熔点: N/A
• 闪点: 1005.5±34.3 °C

DOTATATE用途

DOTATATE 是一种 DOTA 偶联肽,可以被放射性核素标记以用于正电子发射断层扫描 (PET) 成像和肽受体放射性核素治疗 (PRRT)。

DOTATATE名称

• 英文名: N-({(4R,7S,10S,13R,16R,19R)-10-(4-Aminobutyl)-16-(4-hydroxybenzyl)-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-[(N-{[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetyl}-D-phenylalanyl)amino]-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)threonine

DOTATATE生物活性

• 描述: DOTATATE 是一种 DOTA 偶联肽,可以被放射性核素标记以用于正电子发射断层扫描 (PET) 成像和肽受体放射性核素治疗 (PRRT)。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 体内研究: 177Lu多他酸盐对大鼠具有良好的抗肿瘤作用[1]。
• 参考文献:

  [1]. Jong M, et, al. Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogs. J Nucl Med. 2005 Jan;46 Suppl 1:13S-7S.

  [2]. Gains JE, et, al. 68Ga-DOTATATE and 123I-mIBG as imaging biomarkers of disease localisation in metastatic neuroblastoma: implications for molecular radiotherapy. Nucl Med Commun. 2020 Aug 10.

  [3]. Breeman WAP, et, al. Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activities. Eur J Nucl Med Mol Imaging. 2003 Jun;30(6):917-20.

  [4]. Reubi JC, et, al. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med. 2000 Mar;27(3):273-82.

DOTATATE物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 1738.9±65.0 °C at 760 mmHg
• 分子式: C₆₅H₉₀N₁₄O₁₉S₂
• 分子量: 1435.623
• 闪点: 1005.5±34.3 °C
• 精确质量: 1434.594849
• LogP: 0.15
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.688

DOTATATE英文别名

• N-({(4R,7S,10S,13R,16R,19R)-10-(4-Aminobutyl)-16-(4-hydroxybenzyl)-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-[(N-{[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetyl}-D-phenylalanyl)amino]-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)threonine
• Threonine, N-[[(4R,7S,10S,13R,16R,19R)-10-(4-aminobutyl)-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-[[(2R)-1-oxo-3-phenyl-2-[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]propyl]amino]-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-4-yl]carbonyl]-