CB 300919

• 常用名: CB 300919
• 英文名: CB 300919
• CAS号: 289715-28-2
• 分子量: 584.11100
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₂H₃₄ClN₇O₂
• 熔点: N/A
• 闪点: N/A

CB 300919用途

CB 300919是CB30865的水溶性类似物,对人CH1卵巢癌外植体的IC50为2 nM。

CB 300919名称

• 中文名: CB 300919
• 英文名: 4-[[7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide

CB 300919生物活性

• 描述: CB 300919是CB30865的水溶性类似物,对人CH1卵巢癌外植体的IC50为2 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> NAMPT
  研究领域 >> 癌症
• 参考文献:

  [1]. Lockman JW, et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt). J. Med. Chem., 2010, 53 (24), pp 8734-87

  [2]. Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45(17), 3692-3702.

CB 300919物理化学性质

• 分子式: C₃₂H₃₄ClN₇O₂
• 分子量: 584.11100
• 精确质量: 583.24600
• PSA: 86.60000
• LogP: 3.56580
• 储存条件: 2-8℃

CB 300919英文别名

• 4-[N-[7-chloro-3-methyl-2-(4-methyl-piperazin-1-yl)methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(pyridin-3-ylmethyl)benzamide
• CS-0523
• UNII-55I8ETE76Y
• 4-[N-[7-chloro-3-methyl-2-(4-methyl-piperazin-1-yl)methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide
• CB 300919