艾曲波帕乙醇胺

更新时间：2024-01-02 15:47:01

艾曲波帕乙醇胺结构式	常用名	艾曲波帕乙醇胺	英文名	Eltrombopag olamine
	CAS号	496775-62-3	分子量	564.633
	密度	N/A	沸点	N/A
	分子式	C₂₉H₃₆N₆O₆	熔点	N/A
	MSDS	N/A	闪点	N/A

艾曲波帕乙醇胺用途

艾曲波帕是一种血小板生成素受体激动剂,用于治疗慢性免疫性血小板减少症的低血小板计数。

中文名	艾曲波帕乙醇胺
英文名	Eltrombopag olamine
英文别名	更多

描述	艾曲波帕是一种血小板生成素受体激动剂,用于治疗慢性免疫性血小板减少症的低血小板计数。
相关类别	信号通路 >> 免疫及炎症 >> 血小板生成素受体研究领域 >> 心血管疾病
参考文献	[1]. Erickson-Miller CL, et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009 Feb;27(2):424-30. [2]. Erickson-Miller CL, et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol. 2005 Jan;33(1):85-93. [3]. McHutchison JG, et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med. 2007 Nov 29;357(22):2227-36. [4]. Jenkins JM, et al. Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood. 2007 Jun 1;109(11):4739-41. [5]. Saleh MN, et al. Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study. Blood. 2013 Jan 17;121(3):537-45.

描述

艾曲波帕是一种血小板生成素受体激动剂,用于治疗慢性免疫性血小板减少症的低血小板计数。

相关类别

信号通路 >> 免疫及炎症 >> 血小板生成素受体

研究领域 >> 心血管疾病

参考文献

[1]. Erickson-Miller CL, et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009 Feb;27(2):424-30.

[2]. Erickson-Miller CL, et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol. 2005 Jan;33(1):85-93.

[3]. McHutchison JG, et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med. 2007 Nov 29;357(22):2227-36.

[4]. Jenkins JM, et al. Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood. 2007 Jun 1;109(11):4739-41.

[5]. Saleh MN, et al. Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study. Blood. 2013 Jan 17;121(3):537-45.

分子式	C₂₉H₃₆N₆O₆
分子量	564.633
精确质量	564.269653
PSA	209.05000
LogP	3.12780
外观性状	粉末
储存条件	-20℃

Eltrombopag olamine

Revolade

Promacta

UNII-4U07F515LG

[1,1'-Biphenyl]-3-carboxylic acid, 3'-[(2Z)-2-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-, compd. with 2-aminoethanol (1:2)

3'-{(2Z)-2-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxy-3-biphenylcarboxylic acid - 2-aminoethanol (1:2)

Eltrombopag diethanolamine salt

Eltrombopag Impurity 1

Eltrombopag (Olamine)