萘普生杂质A

更新时间：2024-01-09 17:40:37

萘普生杂质A结构式	常用名	萘普生杂质A	英文名	O-Desmethylnaproxen
	CAS号	52079-10-4	分子量	216.23300
	密度	N/A	沸点	444.1ºC at 760mmHg
	分子式	C₁₃H₁₂O₃	熔点	182-183ºC
	MSDS	中文版美版	闪点	236.5ºC
	符号	GHS07, GHS09	信号词	Warning

中文名	(S)-2-(6-羟基-2-萘)丙酸
英文名	O-Desmethylnaproxen
中文别名	甲氧萘丙酸杂质A
英文别名	更多

沸点	444.1ºC at 760mmHg
熔点	182-183ºC
分子式	C₁₃H₁₂O₃
分子量	216.23300
闪点	236.5ºC
精确质量	216.07900
PSA	57.53000
LogP	2.73350
外观性状	white
储存条件	2-8°C

符号	GHS07, GHS09
信号词	Warning
危害声明	H302-H317-H400
警示性声明	P273-P280
个人防护装备	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
危害码 (欧洲)	Xn,N
风险声明 (欧洲)	22-43-50/53
安全声明 (欧洲)	36/37-60-61
危险品运输编码	UN 3077 9/PG 3
WGK德国	3
海关编码	2918199090

2-(6-甲氧基-2-萘基)丙酸

23981-80-8

~98%

萘普生杂质A

52079-10-4

文献：Auspex Pharmaceuticals, Inc. Patent: US2007/276042 A1, 2007 ; Location in patent: Page/Page column 58 ; US 20070276042 A1

萘普生

22204-53-1

~83%

萘普生杂质A

52079-10-4

文献：BEZWADA BIOMEDICAL, LLC. Patent: US2010/209469 A1, 2010 ;

未登录

134735-97-0

~95%

萘普生杂质A

52079-10-4

文献：Ferrayoli, Carlos G.; Palacios, Sara M.; Alonso, Ruben A. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 12 p. 1635 - 1638

6-甲基萘乙酸

23981-47-7

萘普生杂质A

52079-10-4

文献：Harrison; Lewis; Nelson; Rooks; Roszkowski; Tomolonis; Fried Journal of medicinal chemistry, 1970 , vol. 13, # 2 p. 203 - 205

萘普生杂质A上游产品 3
CAS号23981-80-8 2-(6-甲氧基-2-萘基)丙酸 CAS号22204-53-1 萘普生 CAS号23981-47-7 6-甲基萘乙酸
萘普生杂质A下游产品 2
CAS号23981-80-8 2-(6-甲氧基-2-萘基)丙酸 CAS号26159-35-3 萘普生杂质E

海关编码	2918199090
中文概述	HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

The pharmacokinetic profile of naproxen suppository in man.

Int. J. Clin. Pharmacol. Ther. Toxicol. 26(4) , 190-3, (1988)

After a rectal dose of 500 mg in a suppository, naproxen is 6-O-demethylated (20%) and glucuronidated (40%), the metabolites are subsequently excreted renally. The elimination half-life is 15.2 +/- 2....

Sulphation of o-desmethylnaproxen and related compounds by human cytosolic sulfotransferases.

Br. J. Clin. Pharmacol. 60(6) , 632-40, (2005)

Naproxen is a nonsteroidal anti-inflammatory drug widely used as an analgesic and anti-inflammatory agent. The conjugated forms of naproxen and O-DMN, its demethylated metabolite, account for 66-92% o...

High-performance liquid chromatographic determination of 6-desmethylnaproxen sulfate in human plasma.

J. Chromatogr. A. 383(2) , 449-55, (1986)