3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇

• 常用名: 3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇
• 英文名: BRL-54443
• CAS号: 57477-39-1
• 分子量: 230.305
• 密度: 1.2±0.1 g/cm3
• 沸点: 431.5±45.0 °C at 760 mmHg
• 分子式: C₁₄H₁₈N₂O
• 熔点: N/A
• 闪点: 214.8±28.7 °C

3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇用途

BRL 54443是5-HT1E/1F受体激动剂,pKi分别为8.7和8.9,比对其它5-HT和多巴胺受体的抑制性高30倍以上。

3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇名称

• 中文名: 3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇
• 英文名: 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol
• 中文别名: 5-羟基-3-(1-甲基哌啶-4-基)吲哚

3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇生物活性

• 描述: BRL 54443是5-HT1E/1F受体激动剂,pKi分别为8.7和8.9,比对其它5-HT和多巴胺受体的抑制性高30倍以上。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Klein MT, et al. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther. 2011 Jun;337(3):860-867.

  [2]. McKune CM, et al. Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. J Pharmacol Exp Ther. 2001 Apr;297(1):88-95.

  [3]. Klein MT, et al. Distribution of 5-ht(1E) receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study. Br J Pharmacol. 2012 Jun;166(4):1290-302.

  [4]. Granados-Soto V, et al. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience. 2010 Jan 20;165(2):561-8.

3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 431.5±45.0 °C at 760 mmHg
• 分子式: C₁₄H₁₈N₂O
• 分子量: 230.305
• 闪点: 214.8±28.7 °C
• 精确质量: 230.141907
• PSA: 39.26000
• LogP: 1.16
• 外观性状: solid | white
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.646
• 储存条件: 2-8°C
• 水溶解性: H2O: 50 mg/mL

3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇安全信息

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26-36
• WGK德国: 3
• 海关编码: 2933990090

3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇英文别名

• 1H-Indol-5-ol, 3-(1-methyl-4-piperidinyl)-
• 5-hydroxy-3-(1-methylpiperidin-4-yl)indole
• UNII-Q2DH1CHI0Y
• 3-(1-methyl-piperidin-4-yl)-indol-5-ol
• 3-(1-Methylpiperidin-4-yl)-1H-indol-5-ol
• BRL-54443
• BRL 54443
• Tocris-1129
• 3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol
• Lopac-B-173
• 3-(1-methylpiperidin-4-yl)1H-indol-5-ol