Aurora Kinase Inhibitor 3

更新时间：2024-01-14 09:17:30

Aurora Kinase Inhibitor 3结构式	常用名	Aurora Kinase Inhibitor 3	英文名	Aurora Kinase Inhibitor 3
	CAS号	879127-16-9	分子量	413.39600
	密度	N/A	沸点	N/A
	分子式	C₂₁H₁₈F₃N₅O	熔点	N/A
	MSDS	中文版美版	闪点	N/A

Aurora Kinase Inhibitor 3用途

Aurora Kinase Inhibitor 3 是一种有效的,选择性 Aurora A 激酶抑制剂,IC50 为 42 nM,同时微弱抑制 EGFR,IC50>10 μM。Aurora Kinase Inhibitor 3 的环丙烷羧酸部分指向 ATP 结合口袋的溶剂暴露区域,并且与其他公开的 AIK 结构相比,活性位点中存在几种诱导的结构变化。

中文名	极光激酶抑制剂III
英文名	N-[3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropanecarboxamide
英文别名	更多

描述	Aurora Kinase Inhibitor 3 是一种有效的,选择性 Aurora A 激酶抑制剂,IC50 为 42 nM,同时微弱抑制 EGFR,IC50>10 μM。Aurora Kinase Inhibitor 3 的环丙烷羧酸部分指向 ATP 结合口袋的溶剂暴露区域,并且与其他公开的 AIK 结构相比,活性位点中存在几种诱导的结构变化。
相关类别	信号通路 >> 表观遗传学 >> 极光激酶信号通路 >> 细胞周期/DNA损伤 >> 极光激酶研究领域 >> 其他
靶点	Aurora A:42 nM (IC50)
参考文献	[1]. Tari LW, et al. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinitydisubstituted pyrimidine inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17(3):688-91.

分子式	C₂₁H₁₈F₃N₅O
分子量	413.39600
精确质量	413.14600
PSA	85.66000
LogP	5.47550
储存条件	-20°C，密闭，干燥

危险品运输编码	NONH for all modes of transport
海关编码	2933599090

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide

Anilinopyrimidine1

2np8

Aurora Kinase Inhibitor III

N-{3-[(4-{[3-(trifluoromethyl)phenyl]amino}pyrimidin-2-yl)amino]phenyl}cyclopropanecarboxamide