NVP-BHG 712

更新时间：2024-01-02 17:48:44

NVP-BHG 712结构式	常用名	NVP-BHG 712	英文名	NVP-BHG712
	CAS号	940310-85-0	分子量	503.478
	密度	1.4±0.1 g/cm3	沸点	N/A
	分子式	C₂₆H₂₀F₃N₇O	熔点	N/A
	MSDS	中文版美版	闪点	N/A
	符号	GHS06	信号词	Danger

NVP-BHG 712用途

NVP-BHG712是EphB4抑制剂,ED50为25 nM,对c-Raf,c-Src和c-Abl的IC50分别为0.395 μM,1.266 μM和1.667 μM。

中文名	4-甲基-3-[[1-甲基-6-(3-吡啶基)-1H-吡唑并[3,4-d]嘧啶-4-基]氨基]-N-[3-(三氟甲基)苯基]苯甲酰胺
英文名	4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide
英文别名	更多

描述	NVP-BHG712是EphB4抑制剂,ED50为25 nM,对c-Raf,c-Src和c-Abl的IC50分别为0.395 μM,1.266 μM和1.667 μM。
相关类别	信号通路 >> 蛋白酪氨酸激酶 >> 艾弗林受体研究领域 >> 癌症
参考文献	[1]. Martiny-Baron G, et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 2010 Sep;13(3):259-67.

密度	1.4±0.1 g/cm3
分子式	C₂₆H₂₀F₃N₇O
分子量	503.478
精确质量	503.168152
PSA	101.11000
LogP	4.05
外观性状	white to beige
折射率	1.666
储存条件	?20°C
水溶解性	DMSO: >15mg/mL

符号	GHS06
信号词	Danger
危害声明	H301
警示性声明	P301 + P310
危害码 (欧洲)	T
风险声明 (欧洲)	25
安全声明 (欧洲)	45
危险品运输编码	UN 2811 6.1 / PGIII

EphB4 forward signalling regulates lymphatic valve development.

Nat. Commun. 6 , 6625, (2015)

Bidirectional signalling is regarded as a notable hallmark of the Eph-ephrin signalling system: Eph-dependent forward signalling in Eph-expressing cells and ephrin-dependent reverse signalling in Ephr...

EPHB4 Protein Expression in Vascular Smooth Muscle Cells Regulates Their Contractility, and EPHB4 Deletion Leads to Hypotension in Mice.

J. Biol. Chem. 290 , 14235-44, (2015)

EPH kinases are the largest family of receptor tyrosine kinases, and their ligands, ephrins (EFNs), are also cell surface molecules. This work presents evidence that EPHB4 on vascular smooth muscle ce...

Effect of EPH-ephrin signaling on the growth of human leukemia cells.

Anticancer Res. 34(6) , 2913-8, (2014)

Signaling induced by binding of erythropoietin-producing hepatoma-amplified sequence (EPH) receptors to their cell-surface ephrin ligands is implicated in hematopoiesis and growth of various cancer ce...

NVP-BHG712

4-Methyl-3-{[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-[3-(trifluoromethyl)phenyl]benzamide

4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide

cc-540

S2202_Selleck