Lanreotide diTFA structure
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Common Name | Lanreotide diTFA | ||
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CAS Number | 1024499-83-9 | Molecular Weight | 1324.37 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C58H71F6N11O14S2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Lanreotide diTFALanreotide (BIM 23014) diTFA is a somatostatin analogue with antineoplastic activity. Lanreotide diTFA can be used for the research of carcinoid syndrome[1][2]. |
Name | Lanreotide diTFA |
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Description | Lanreotide (BIM 23014) diTFA is a somatostatin analogue with antineoplastic activity. Lanreotide diTFA can be used for the research of carcinoid syndrome[1][2]. |
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Related Catalog | |
In Vitro | Lanreotide (BIM 23014) (100 nM; 0-48 h) enhanced radiation-induced apoptosis[1]. Lanreotide results in a dose-dependent decrease in GH3 cell colony forming units. Lanreotide at concentrations of 1, 10, 100, and 1000 nM results in cell survival rates of 75, 56, 39 and 27% respectively. The IC50 is 57 nM[1]. Lanreotide inhibits GH-secreting pituitary adenoma cell proliferation and hormone release in vitro[2]. Apoptosis Analysis[1] Cell Line: GH3 Concentration: 100 nM Incubation Time: 48 h, 24 h, or immediately (0 h) before radiation Result: Increased apoptotic sub-G1 proportion compared with radiation alone. |
In Vivo | Lanreotide (2.5-10mg/kg; s.c.; daily for 5 days) results in tumor growth inhibition[1]. Animal Model: Male nude mice, 8 weeks old and 20–25 g in body weight (GH3 tumor-bearing nude mice)[1] Dosage: 2.5, 5, 10 mg/kg Administration: Subcutaneous; daily for 5 days Result: Produced tumor growth inhibition. |
References |
Molecular Formula | C58H71F6N11O14S2 |
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Molecular Weight | 1324.37 |