![]() TAK-603 structure
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Common Name | TAK-603 | ||
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CAS Number | 158146-85-1 | Molecular Weight | 478.50 | |
Density | 1.29g/cm3 | Boiling Point | 640.7ºC at 760 mmHg | |
Molecular Formula | C25H26N4O6 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 341.3ºC |
Use of TAK-603TAK-603 is a potent and orally active antirheumatic agent. TAK-603 inhibits Thl-type cytokine production. TAK-603 has the potential for the research of adjuvant arthritis[1][2]. |
Name | ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate |
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Synonym | More Synonyms |
Description | TAK-603 is a potent and orally active antirheumatic agent. TAK-603 inhibits Thl-type cytokine production. TAK-603 has the potential for the research of adjuvant arthritis[1][2]. |
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Related Catalog | |
In Vitro | TAK-603 (0, 1, 10 µM; 48 h) 抑制同种异体反应性和 OVA 反应性 BALB/c 小鼠 T 细胞系中的 IFN-γ 的产生,但对 IL-4 产生几乎没有影响 [2]. |
In Vivo | TAK-603 (6.25 mg/kg;口服;每天) 减少关节炎病变和脾脏中 Thl-型细胞因子的产生[2]。 Animal Model: AA rats[2] Dosage: 6.25 mg/kg Administration: P.o.; daily Result: Inhibited arthritic paw swelling with the inhibition rate of 65% and the IFN-y mRNA expression in the arthritic joint was significantly reduced. |
References |
Density | 1.29g/cm3 |
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Boiling Point | 640.7ºC at 760 mmHg |
Molecular Formula | C25H26N4O6 |
Molecular Weight | 478.50 |
Flash Point | 341.3ºC |
Exact Mass | 478.18500 |
PSA | 106.82000 |
LogP | 3.75270 |
Vapour Pressure | 2.59E-16mmHg at 25°C |
Index of Refraction | 1.604 |
3-Quinolinecarboxylic acid,4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1H-1,2,4-triazol-1-ylmethyl)-,ethyl ester |
ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate |
ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1H-1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate |
6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester |
ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(4H-1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate |
Ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1H-1,2,4-triazol-1-ylmethyl)-3-quinolinecarboxylate |
4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester |