L-Kynurenine-d4-1

Modify Date: 2024-09-18 11:45:11

L-Kynurenine-d4-1 Structure
L-Kynurenine-d4-1 structure
Common Name L-Kynurenine-d4-1
CAS Number 194546-33-3 Molecular Weight 212.24
Density N/A Boiling Point N/A
Molecular Formula C10H8D4N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of L-Kynurenine-d4-1


L-Kynurenine-d4-1 is deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

 Names

Name L-Kynurenine-d4-1

 L-Kynurenine-d4-1 Biological Activity

Description L-Kynurenine-d4-1 is deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Moyer BJ, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24.

[3]. Sakakibara K, et al. Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K(+) channels. J Pharmacol Sci. 2015 Sep;129(1):31-7.

[4]. Nozaki K, et al. Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats. J Cereb Blood Flow Metab. 1992 May;12(3):400-7.

 Chemical & Physical Properties

Molecular Formula C10H8D4N2O3
Molecular Weight 212.24