Bempedoic acid-d5

Modify Date: 2024-01-12 08:42:09

Bempedoic acid-d5 structure	Common Name	Bempedoic acid-d5
	CAS Number	2408131-71-3	Molecular Weight	349.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₃₁D₅O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Bempedoic acid-d5

Bempedoic acid-d5 is the deuterium labeled Bempedoic acid[1]. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].

Name	Bempedoic acid-d5

Description	Bempedoic acid-d5 is the deuterium labeled Bempedoic acid[1]. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Signaling Pathways >> Metabolic Enzyme/Protease >> ATP Citrate Lyase Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Pinkosky SL, et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013 Jan;54(1):134-51. [3]. Filippov S, et al. ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK. J Lipid Res. 2013 Aug54(8):2095-108.

Molecular Formula	C₁₉H₃₁D₅O₅
Molecular Weight	349.52