DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt

Modify Date: 2024-01-09 18:39:29

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt Structure
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt structure
Common Name DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt
CAS Number 263718-22-5 Molecular Weight 1507.75000
Density N/A Boiling Point N/A
Molecular Formula C76H98N16O15S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt


DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite[1].

 Names

Name Malaria Aspartyl Proteinase FRET Substrate I,[DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS]
Synonym More Synonyms

  Biological Activity

Description DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite[1].
Related Catalog
In Vitro DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS (10 μM) can be used in the plasmepsin assay to mimic the cleavage site present in hemoglobin (kcat: 0.78 /s, Km: 0.10 μM, for P. falciparum plasmepsin; and kcat: 0.69 /s, Km: 0.16 μM, for P. vivaxplasmepsin.
References

[1]. S Jiang, et al. New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins. Antimicrob Agents Chemother. 2001 Sep;45(9):2577-84.

 Chemical & Physical Properties

Molecular Formula C76H98N16O15S
Molecular Weight 1507.75000
Exact Mass 1506.71000
PSA 475.28000
LogP 10.04630

 Synonyms

MALARIA ASPARTYL PROTEINASE SUBSTRATE
MALARIA ASPARTYL PROTEINASE FRET SUBSTRATE I
DABCYL-GLU-ARG-NLE-PHE-LEU-SER-PHE-PRO-EDANS
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt