Lercanidipine-13C,d3-1 hydrochloride

Modify Date: 2024-01-10 12:31:57

Lercanidipine-13C,d3-1 hydrochloride Structure
Lercanidipine-13C,d3-1 hydrochloride structure
Common Name Lercanidipine-13C,d3-1 hydrochloride
CAS Number 2747918-20-1 Molecular Weight 652.20
Density N/A Boiling Point N/A
Molecular Formula C3513CH39D3ClN3O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lercanidipine-13C,d3-1 hydrochloride


Lercanidipine-13C,d3-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[1][2][3].

 Names

Name Lercanidipine-13C,d3-1 hydrochloride

 Lercanidipine-13C,d3-1 hydrochloride Biological Activity

Description Lercanidipine-13C,d3-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[1][2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70.

[3]. Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7.

[4]. Grassi G, et, al. Lercanidipine in the Management of Hypertension: An Update. J Pharmacol Pharmacother. Oct-Dec 2017;8(4):155-165.

 Chemical & Physical Properties

Molecular Formula C3513CH39D3ClN3O6
Molecular Weight 652.20