Triflusal-d3

Modify Date: 2024-01-05 15:40:18

Triflusal-d3 structure	Common Name	Triflusal-d3
	CAS Number	2748541-63-9	Molecular Weight	251.17
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀H₄D₃F₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Triflusal-d3

Triflusal-d3 is deuterium labeled Triflusal.

Name	Triflusal-d3

Description	Triflusal-d3 is deuterium labeled Triflusal.
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Fernández de Arriba A, et al. Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid. Mol Pharmacol. 1999 Apr;55(4):753-60. [3]. Duran, X., et al., Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2. J Thromb Haemost, 2008. 6(8): p. 1385-92. [4]. De Miguel, L.S., et al., A 4-trifluoromethyl derivative of salicylate, triflusal, stimulates nitric oxide production by human neutrophils: role in platelet function. Eur J Clin Invest, 2000. 30(9): p. 811-7.

Molecular Formula	C₁₀H₄D₃F₃O₄
Molecular Weight	251.17