ALK5-IN-33
Modify Date: 2024-04-07 10:06:29
ALK5-IN-33 structure
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Common Name | ALK5-IN-33 | ||
|---|---|---|---|---|
| CAS Number | 2785430-89-7 | Molecular Weight | 413.48 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H23N7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ALK5-IN-33ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM[1]. |
| Name | ALK5-IN-33 |
|---|
| Description | ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM[1]. |
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| Related Catalog | |
| Target |
ALK5:≤10 nM (IC50) ALK2 |
| In Vitro | ALK-IN-33 (Compound EX-10) shows a high efficiency by inducing a full inhibition (max PIN greater than 75) of TGF-β1 mediated alpha-SMA expression, in at least two donors[1]. |
| In Vivo | ALK-IN-33 (Compound EX-10) (10-100 mg/kg; i.g.; once) reduces the phospho SMAD2 levels in a dose dependent fashion in A549 xenograft model in mice[1]. Animal Model: Female athymic nude mice, A549 xenograft model[1] Dosage: 10, 50, 75 and 100 mg/kg Administration: Oral gavage, once Result: Reduced the phospho SMAD2 levels (p-SMAD2) in a dose dependent fashion. |
| References |
[1]. Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1. |
| Molecular Formula | C23H23N7O |
|---|---|
| Molecular Weight | 413.48 |