D-(2H3)Methionine

Modify Date: 2024-01-09 16:58:46

D-(2H3)Methionine structure	Common Name	D-(2H3)Methionine
	CAS Number	284665-18-5	Molecular Weight	152.23
	Density	1.2±0.1 g/cm3	Boiling Point	306.9±37.0 °C at 760 mmHg
	Molecular Formula	C₅H₈D₃NO₂S	Melting Point	N/A
	MSDS	USA	Flash Point	139.4±26.5 °C

Use of D-(2H3)Methionine

Methionine-d3 is the deuterium labeled Methionine. Methionine (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.

Name	(2R)-2-amino-4-(trideuteriomethylsulfanyl)butanoic acid
Synonym	More Synonyms

Description	Methionine-d3 is the deuterium labeled Methionine. Methionine (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Wu C, et al. Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition. J Neural Transm (Vienna). 2014 Jul;121(7):683-93. [3]. Sooriyaarachchi M, et al. Chemoprotection by D-methionine against cisplatin-induced side-effects: insight from in vitrostudies using human plasma. Metallomics. 2014 Mar;6(3):532-41. [4]. Hinduja S, et al. D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat. Neurotox Res. 2015 Apr;27(3):199-204.

Density	1.2±0.1 g/cm3
Boiling Point	306.9±37.0 °C at 760 mmHg
Molecular Formula	C₅H₈D₃NO₂S
Molecular Weight	152.23
Flash Point	139.4±26.5 °C
Exact Mass	152.069885
PSA	88.62000
LogP	0.37
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.531

D-(2H3)Methionine MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

D-Methionine-methyl-d3

D-Methionine-d

D-(H)Methionine

D-(2H3)Methionine

Use of D-(2H3)Methionine

Names

D-(2H3)Methionine Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synonyms