N,N-Bis[(2H3)methyl]acetamide

Modify Date: 2024-01-13 12:30:09

N,N-Bis[(2H3)methyl]acetamide Structure
N,N-Bis[(2H3)methyl]acetamide structure
Common Name N,N-Bis[(2H3)methyl]acetamide
CAS Number 31591-08-9 Molecular Weight 93.157
Density 0.9±0.1 g/cm3 Boiling Point 166.1±0.0 °C at 760 mmHg
Molecular Formula C4H3D6NO Melting Point N/A
MSDS N/A Flash Point 70.0±0.0 °C

 Use of N,N-Bis[(2H3)methyl]acetamide


N,N-Dimethylacetamide-d6 is the deuterium labeled N,N-Dimethylacetamide[1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent[2].

 Names

Name n,n-dimethyl-d6-acetamide
Synonym More Synonyms

 N,N-Bis[(2H3)methyl]acetamide Biological Activity

Description N,N-Dimethylacetamide-d6 is the deuterium labeled N,N-Dimethylacetamide[1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Sundaram S, et al. N,N-dimethylacetamide regulates the proinflammatory response associated with endotoxin and prevents preterm birth. Am J Pathol. 2013 Aug;183(2):422-30.  

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 166.1±0.0 °C at 760 mmHg
Molecular Formula C4H3D6NO
Molecular Weight 93.157
Flash Point 70.0±0.0 °C
Exact Mass 93.106071
PSA 20.31000
LogP -0.75
Vapour Pressure 1.8±0.3 mmHg at 25°C
Index of Refraction 1.407

 Synonyms

N,N-dimethylacetamide-d6
N,N'-Bis-thiazol-2-yl-malonamide
N,N'-Bis-thiazol-2-yl-malonamid
d6-N,N-Dimethylacetamid
Acetamide, N,N-di(methyl-d)-
N,N-Bis[(H)methyl]acetamide
N,N-bis-trideuteriomethyl-acetamide