PIPES-d18

Modify Date: 2024-01-14 13:07:04

PIPES-d18 structure	Common Name	PIPES-d18
	CAS Number	352534-95-3	Molecular Weight	320.47900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈D₁₈N₂O₆S₂	Melting Point	>300ºC
	MSDS	USA	Flash Point	N/A

Use of PIPES-d18

PIPES-d18 is the deuterium labeled PIPES[1]. PIPES (1,4-Piperazinediethanesulfonic acid) is an important component of PIPES buffer agent used in biochemistry[2].

Name	piperazine-n,n'-bis(2-ethanesulfonic acid)-d18

Description	PIPES-d18 is the deuterium labeled PIPES[1]. PIPES (1,4-Piperazinediethanesulfonic acid) is an important component of PIPES buffer agent used in biochemistry[2].
Related Catalog	Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Jason Moggridge, et al. Sensitive Detection of Immunoglobulin G Stability Using in Real-Time Isothermal Differential Scanning Fluorimetry: Determinants of Protein Stability for Antibody-Based Therapeutics. Technol Cancer Res Treat. 2017 Dec;16(6):997-1005.

Melting Point	>300ºC
Molecular Formula	C₈D₁₈N₂O₆S₂
Molecular Weight	320.47900
Exact Mass	320.17400
PSA	131.98000
LogP	0.41700