JTC-017

Modify Date: 2024-01-31 01:14:10

JTC-017 structure	Common Name	JTC-017
	CAS Number	357330-77-9	Molecular Weight	490.40100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₅Cl₂N₃O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JTC-017

JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].

Name	3,5-dichloro-N-[5-(diethylsulfamoyl)-3-(dimethylamino)-2-methoxyphenyl]-4-hydroxybenzamide
Synonym	More Synonyms

Description	JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CRFR Research Areas >> Metabolic Disease
References	[1]. Saito K, et al. Corticotropin-releasing hormone receptor 1 antagonist blocks brain-gut activation induced by colonic distention in rats. Gastroenterology. 2005;129(5):1533-1543.

Molecular Formula	C₂₀H₂₅Cl₂N₃O₅S
Molecular Weight	490.40100
Exact Mass	489.08900
PSA	111.05000
LogP	5.52120

Benzamide,3,5-dichloro-N-(5-((diethylamino)sulfonyl)-3-(dimethylamino)-2-methoxyphenyl)-4-hydroxy

JTC-017

UNII-7F4TZ7XGMO

JTC-017

Use of JTC-017

Names

JTC-017 Biological Activity

Chemical & Physical Properties

Synonyms