Muscimol hydrochloride

Modify Date: 2024-07-24 08:40:37

Muscimol hydrochloride structure	Common Name	Muscimol hydrochloride
	CAS Number	3579-03-1	Molecular Weight	150.56
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄H₇ClN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Muscimol hydrochloride

Muscimol (Agarin; Agarine) hydrochloride is an isoxazole with psychoactive activity. Muscimol hydrochloride is also a selective agonist of the inhibitory neurotransmitter, GABA ionotropic receptors. Muscimol hydrochloride can be isolated from from Amanita muscaria and related mushrooms. All in all, Muscimol is a potent GABAA receptors agonist (EC50=0.2 μM), a partial GABACreceptors agonist, and an inactive GABAB receptors agonist. Muscimol hydrochloride has calming, anti-anxiety and hallucinatory effects[1].

Name	5-(aminomethyl)isoxazol-3-ol hydrochloride

Description	Muscimol (Agarin; Agarine) hydrochloride is an isoxazole with psychoactive activity. Muscimol hydrochloride is also a selective agonist of the inhibitory neurotransmitter, GABA ionotropic receptors. Muscimol hydrochloride can be isolated from from Amanita muscaria and related mushrooms. All in all, Muscimol is a potent GABAA receptors agonist (EC50=0.2 μM), a partial GABACreceptors agonist, and an inactive GABAB receptors agonist. Muscimol hydrochloride has calming, anti-anxiety and hallucinatory effects[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	EC50: 0.2 μM (GABACreceptors)[1]
In Vivo	Muscimol 影响前额叶皮层的功能，并且在注射到腹侧前额叶皮层后（1μL，5μg/μL；前额叶皮层输注），损害猴子在计数任务中的表现，但在注射到背侧前额叶皮层后没有影响[2]。 Muscimol 影响前扣带皮层 (ACC) 的微量调节，并且在 10 秒微量组中（62.5 或 125 µg/侧）对抑制噪声刺激没有影响[3]。 Animal Model: Female rhesus monkeys (Macaca mulatta) (5 kg and 5.5 kg)[2] Dosage: 1 μL, 5 μg/μL Administration: Implanted drug delivery tubes and infusion; single dose Result: Increased the error types and reaction time during the counting task.
References	[1]. Johnston GA. Muscimol as an ionotropic GABA receptor agonist. Neurochem Res. 2014 Oct;39(10):1942-7. [2]. Sun W, et al. Muscimol-induced inactivation of the ventral prefrontal cortex impairs counting performance in rhesus monkeys. Sci Prog. 2022 Oct-Dec;105(4):368504221141660. [3]. Pezze MA, et al. Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat. J Psychopharmacol. 2020 Dec;34(12):1457-1460.

Molecular Formula	C₄H₇ClN₂O₂
Molecular Weight	150.56
Exact Mass	150.02000
PSA	72.28000
LogP	1.34120

Precursor 0
DownStream 1
CAS#:2763-96-4 Muscimol

Muscimol hydrochloride

Use of Muscimol hydrochloride

Names

Muscimol hydrochloride Biological Activity

Chemical & Physical Properties

Precursor & DownStream