TSPO ligand-1
Modify Date: 2024-01-19 14:36:26
TSPO ligand-1 structure
|
Common Name | TSPO ligand-1 | ||
|---|---|---|---|---|
| CAS Number | 4560-08-1 | Molecular Weight | 283.71 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H10ClNO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TSPO ligand-1TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration[1][2]. |
| Name | TSPO ligand-1 |
|---|
| Description | TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | TSPO ligand-1 gene is induced to increase expression in the context of selective activation of neurons in male C57Bl6/N mice. Moreover, neuronal activation under physiological and psychopharmacological conditions also results in increased TSPO levels in adult mice[2]. TSPO ligand-1 can serve as the sole marker of glial cell activity in Alzheimer’s disease thus tracking the formation of different neural cells[3]. TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus effects mitochondrial energy homeostasis in MA-10 Leydig cell line[4]. |
| References |
| Molecular Formula | C16H10ClNO2 |
|---|---|
| Molecular Weight | 283.71 |