Neural tissue regeneration in experimental brain injury model with channeled scaffolds of acrylate copolymers.

Cristina Martínez-Ramos, Ulises Gómez-Pinedo, Maria Angeles Garcia Esparza, José Miguel Soria, Juan A Barcia, Manuel Monleón Pradas

Index: Neurosci. Lett. 598 , 96-101, (2015)

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Abstract

The objective of the present study was to evaluate the biocompatibility and cell hosting ability of a copolymer scaffold based on ethyl acrylate (EA) and hydroxyl ethyl acrylate (HEA) in vivo after an experimental brain injury. Wistar rats were subjected to cryogenic traumatic brain injury. We evaluated the tissue response to the implanted materials after 8 weeks. The materials were implanted devoid of cells; they provoked a minimal scar response by the host tissue and permitted the invasion of neurons and glia inside them. We also found new blood vessels surrounding and inside the implant. Thus, the copolymer scaffold proves to offer a suitable environment producing a cellular network potentially useful in brain repair after brain injury. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.