Pharmazie 2007-01-01

Antidepressant activity of sarsasapogenin from Anemarrhena asphodeloides Bunge (Liliaceae).

L X Ren, Y F Luo, X Li, Y L Wu

Index: Pharmazie 62(1) , 78-9, (2007)

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Abstract

The aim of this study was to investigate the effects of sarsasapogenin from Anemarrhena asphodeloides Bunge (Liliaceae) on two experimental models of depression in rats. After a two-week treatment, sarsasapogenin markedly shortened the immobility time in the forced swimming test and decreased the number of escape deficits in the learned helplessness paradigm, however, locomotor activity was not affected.

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