Gaucher's disease and glioblastoma multiforme in two siblings: a clinicopathologic study.
J C Lyons, B W Scheithauer, W W Ginsburg
Index: J. Neuropathol. Exp. Neurol. 41(1) , 45-53, (1982)
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Abstract
The clinical and pathologic features of two brothers with the adult form of Gaucher's disease, both of whom developed cerebral glioblastoma multiforme, are presented. Neither patient had a long-standing neurologic disorder, and morphologic evidence of nervous system glucocerebroside storage was not seen. Despite the known increased incidence of malignancy in Gaucher's disease, a review of the literature and of sixty-two Mayo Clinic cases of adult onset Gaucher's disease revealed only one other instance of the association with glioma. The significance of the relationship is unknown.
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