Journal of Neuropathology & Experimental Neurology 1982-03-01

Ultrastructure of hypothalamic and medullary lesions caused by an aliphatic triamine.

D Nochlin, S Levine

Index: J. Neuropathol. Exp. Neurol. 41(2) , 233-40, (1982)

Full Text: HTML

Abstract

The administration of an aliphatic triamine, 3,3'-methylimino-bis-(N-methylpropylamine), was used to produce non-necrotizing lesions in the hypothalamus and medulla oblongata of rats. The distribution of the lesions in the hypothalamus was similar to that produced by goldthioglucose, and consisted ultrastructurally of marked distention and edema of the extracellular space, with no confined to the dorsal aspect, in the region of the area postrema. The data suggest that the absence of blood-brain barrier in these sites plays a role in the production of lesions, at least in the initial stages, as has been proposed for goldthioglucose lesions.


Related Compounds

Related Articles:

Gold thioglucose, mimpa and lesions of the ventromedial hypothalamus.

1984-07-01

[J. Neuropathol. Exp. Neurol. 43(4) , 455-7, (1984)]

Gaucher's disease and glioblastoma multiforme in two siblings: a clinicopathologic study.

1982-01-01

[J. Neuropathol. Exp. Neurol. 41(1) , 45-53, (1982)]

Localization of toxic encephalopathies near lesions of experimental allergic encephalomyelitis.

1982-05-01

[Am. J. Pathol. 107(2) , 135-41, (1982)]

The effect of alloxan-induced diabetes on triamine lesions in the ventromedial hypothalamus.

1991-01-01

[Physiol. Behav. 49(1) , 41-6, (1991)]

Periventricular localization of a toxic encephalopathy induced by a mechanism involving choroid plexus.

1982-06-24

[Brain Res. 242(2) , 219-25, (1982)]

More Articles...