Environmental Toxicology and Pharmacology 2014-09-01

Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression

Mohamed R. Mohamed, Manal A. Emam, Nahla S. Hassan, Abeer I. Mogadem

Index: Environ. Toxicol. Pharmacol. 38(2) , 531-41, (2014)

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Abstract

• This study demonstrates the hepatoprotective effect of umbelliferone and daphnetin. • Both coumarins ameliorate CCl4-induced oxidative stress and hepatotoxicity. • This effect is mediated via the nuclear translocation and accumulation of Nrf2. • Nrf2 up-regulates the expression and thus activity of the cytoprotective HO-1. • This study highlights the therapeutic potential of these coumarin derivatives.

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