Carbon tetrachloride

Names

[ CAS No. ]:
56-23-5

[ Name ]:
Carbon tetrachloride

[Synonym ]:
tert-butyl N-acetate
EINECS 203-453-4
tetrachloro-methane
1,1-Dimethyl acetate
tert-Butyl ethanoate
anhydrous tert-butyl acetate
Carbon tetrachloride
tert-BuOCOCH3
carbone tetrachloride
acetic acid tert-butyl ester
anhydrous tetra-chloro-methane
carbon chloride
Acetic acid,1,1-dimethylethyl ester
t-Butyl acetate
Texaco lead appreciator
1,1-dimethylethyl acetate
MFCD00006998

Biological Activity

[Description]:

Carbon tetrachloride is a colorless nonflammable liquid. Carbon tetrachloride induces acute liver injury through the sympathetic nervous pathway. Carbon tetrachloride induces liver fibrosis and hepatotoxicity. Carbon tetrachloride is orally active[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Nakade Y, et al. Involvement of endogenous CRF in carbon tetrachloride-induced acute liver injury in rats. Am J Physiol Regul Integr Comp Physiol. 2002 Jun;282(6):R1782-8.

[2]. Ma N, et al. MiR-552-3p Regulates Multiple Fibrotic and Inflammatory genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes. Int J Biol Sci. 2023 Jul 3;19(11):3456-3471.

[3]. Kondeva-Burdina M, et al. In Vitro/In Vivo Hepatoprotective and Antioxidant Effects of Defatted Extract and a Phenolic Fraction Obtained from Phlomis Tuberosa. Int J Mol Sci. 2023 Jun 25;24(13):10631.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
76.0±8.0 °C at 760 mmHg

[ Melting Point ]:
-23 °C

[ Molecular Formula ]:
CCl₄

[ Molecular Weight ]:
153.82

[ Flash Point ]:
-0.3±15.8 °C

[ Exact Mass ]:
151.875412

[ LogP ]:
2.86

[ Vapour density ]:
5.32 (vs air)

[ Vapour Pressure ]:
112.7±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.487

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
0.8 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H317-H351-H372-H412-H420

[ Precautionary Statements ]:
P261-P273-P280-P301 + P310 + P330-P403 + P233-P502

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R23/24/25;R40;R48/23;R52/53;R59

[ Safety Phrases ]:
S23-S36/37-S45-S59-S61

[ RIDADR ]:
UN 1846 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
FG4900000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2903140090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2903140090

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